HIV and antiretroviral therapy-related fat alterations

JR Koethe, C Lagathu, JE Lake, P Domingo… - Nature reviews Disease …, 2020 - nature.com
Early in the HIV epidemic, lipodystrophy, characterized by subcutaneous fat loss
(lipoatrophy), with or without central fat accumulation (lipohypertrophy), was recognized as a …

Adipogenesis: cellular and molecular aspects

B Fève - Best Practice & Research Clinical Endocrinology & …, 2005 - Elsevier
Obesity and lipoatrophy are major risks for insulin resistance, non-insulin-dependent
diabetes and cardiovascular disease. In the past three decades, significant advances have …

Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 …

M Tiikkainen, AM Häkkinen, E Korsheninnikova… - Diabetes, 2004 - Am Diabetes Assoc
Both rosiglitazone and metformin increase hepatic insulin sensitivity, but their mechanism of
action has not been compared in humans. The objective of this study was to compare the …

Adipocyte differentiation

JM Moreno-Navarrete, JM Fernández-Real - Adipose tissue biology, 2017 - Springer
Adipocyte differentiation is a highly controlled process that has been extensively studied for
the last 25 years. Two different kinds of in vitro experimental models, essential in …

Regulation of adiponectin expression in human adipocytes: effects of adiposity, glucocorticoids, and tumor necrosis factor α

M Degawa‐Yamauchi, KA Moss… - Obesity …, 2005 - Wiley Online Library
Objective: Adiponectin mRNA expression in isolated subcutaneous and omental adipocytes
was examined across a wide range of adiposity to determine whether adiponectin synthesis …

Molecular mechanisms of human lipodystrophies: from adipocyte lipid droplet to oxidative stress and lipotoxicity

C Vigouroux, M Caron-Debarle, C Le Dour… - The international journal …, 2011 - Elsevier
Adipose tissue is now recognized for its major role in the control of energy metabolism and
insulin sensitivity. We review here the human lipodystrophies, that are rare conditions in …

Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages

C Lagathu, B Eustace, M Prot, D Frantz, Y Gu… - Antiviral …, 2007 - journals.sagepub.com
Objectives Adipose tissue from patients with HIV-related lipodystrophy presents a state of
chronic inflammation. Altered expression of cytokines/adipokines and macrophage …

A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-α)-like effector A (CIDEA) in adipocyte lipolysis and obesity

EA Nordstrom, M Rydén, EC Backlund, I Dahlman… - Diabetes, 2005 - Am Diabetes Assoc
Elevated circulating fatty acid concentration is a hallmark of insulin resistance and is at least
in part attributed to the action of adipose tissue-derived tumor necrosis factor-α (TNF-α) on …

The bovine PPARGC1A gene: molecular characterization and association of an SNP with variation of milk fat synthesis

R Weikard, C Kühn, T Goldammer… - Physiological …, 2005 - journals.physiology.org
Several studies in a variety of breeds have reported at least two QTL for milk production
traits, including milk fat synthesis on bovine chromosome 6 (BTA6), comprising a region that …

Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic …

V Jan, P Cervera, M Maachi, M Baudrimont… - Antiviral …, 2004 - journals.sagepub.com
Objective To achieve a better understand of the pathophysiology of HIV-related lipoatrophy,
we compared the mRNA expression of adipocytokines in fat samples from patients and …