Recent advances in acid–base physiology and in the epidemiology of acid–base disorders
have refined our understanding of the basic control mechanisms that determine blood pH in …

Background: Intensivists spend much of their time managing problems related to fluids,
electrolytes, and blood pH. Recent advances in the understanding of acid-base physiology …

PURPOSE: The aim of the study was to determine if acid-base variables are associated with
hospital mortality. MATERIALS AND METHODS: This prospective cohort study took place in …

Introduction Acute metabolic acidosis of non-renal origin is usually a result of either lactic or
ketoacidosis, both of which are associated with a high anion gap. There is increasing …

Abstract Purpose To determine whether Stewart's approach can improve our ability to
diagnose acid–base disorders compared to the traditional model. Methods This prospective …

Background Lactate concentration is a robust predictor of mortality but in many low resource
settings facilities for its analysis are not available. Anion gap (AG), calculated from clinical …

Objective: The physicochemical approach, described by Stewart to investigate the acid–
base balance, includes the strong ion gap (SIG), a quantitative measure of “unmeasured” …

Background Acid–base disturbances are frequently observed in critically ill patients at the
intensive care unit. To our knowledge, the acid–base profile of patients with acute-on …

PURPOSE: This study aimed to test the hypothesis that intensive care unit survivors and
nonsurvivors differ with regard to type and severity of acid-base disorders. MATERIALS AND …

Objective: We hypothesized that the delta anion gap defined as difference between critical
care initiation standard anion gap and prehospital admission standard anion gap is …