Inhibition of NF-κB and ERK signaling pathways in osteoclasts and M1 macrophage polarization: Mechanistic insights into the anti-osteoporotic effects of Pseudolaric …

L Liu, C Xiang, T Li, Z Zhao, T Xiao, Z Ouyang - Life Sciences, 2024 - Elsevier
Osteoporosis, characterized by bone metabolism disruption leading to gradual bone loss
and increased fracture susceptibility, is linked to the excessive activation of osteoclasts …

P129, a pyrazole ring-containing isolongifolanone-derivate: synthesis and investigation of anti-glioma action mechanism

Y Jiang, Y Wang, L Zhao, W Yang, L Pan, Y Bai… - Discover Oncology, 2024 - Springer
Background Cyclin-dependent kinase-2 (CDK-2) is an important regulatory factor in the G
1/S phase transition. CDK-2 targeting has been shown to suppress the viability of multiple …