The human upper respiratory tract (URT) offers a variety of niches for microbial colonization.
Local microbial communities are shaped by the different characteristics of the specific …

With the discovery of the CFTR gene in 1989, the search for therapies to improve the basic
defects of cystic fibrosis (CF) commenced. Pharmacological manipulation provides the …

Rationale: Cystic fibrosis (CF) is characterized by early structural lung disease caused by
pulmonary infections. The nasopharynx of infants is a major ecological reservoir of potential …

Objectives To quantify airway and artery (AA)-dimensions in cystic fibrosis (CF) and control
patients for objective CT diagnosis of bronchiectasis and airway wall thickness (AWT) …

Purpose Computed tomography (CT) and magnetic resonance imaging (MRI) scans are
used to assess and monitor several pediatric lung diseases. It is well recognized that lung …

Monitoring of pulmonary physiology is fundamental to the clinical management of patients
with Cystic Fibrosis. The current standard clinical practise uses spirometry to assess lung …

Background Primary ciliary dyskinesia is a rare genetic disorder characterized by recurrent
sinopulmonary infections and worsening obstructive lung disease. Kidney and brain …

Introduction Chest computed tomography (CT) examinations are performed routinely in
some cystic fibrosis (CF) centers in order to evaluate lung disease progression in CF …

Despite our current treatment, many cystic fibrosis (CF) patients still show progressive
bronchiectasis and small airways disease. Adequate detection and monitoring of …

Background Electrical impedance tomography (EIT) delivers information about global and
regional ventilation. Linearity of EIT during tidal breathing is known. We investigated the …