HLA-G: An important mediator of maternal-fetal immune-tolerance

B Zhuang, J Shang, Y Yao - Frontiers in Immunology, 2021 - frontiersin.org
Maternal-fetal immune-tolerance occurs throughout the whole gestational trimester, thus a
mother can accept a genetically distinct fetus without immunological aggressive behavior …

Heterogeneity of HLA-G expression in cancers: facing the challenges

A Lin, WH Yan - Frontiers in immunology, 2018 - frontiersin.org
Phenotypic heterogeneity has been observed in most malignancies, which represents a
considerable challenge for tumor therapy. In recent decades, the biological function and …

HLA-G: a new immune checkpoint in cancer?

D Krijgsman, J Roelands, W Hendrickx… - International journal of …, 2020 - mdpi.com
Human leukocyte antigen G (HLA-G), known as a central protein in providing immune
tolerance to the fetus in pregnant women, is also studied for a possible role in tumor …

Insights into HLA-G Genetics Provided by Worldwide Haplotype Diversity

EC Castelli, J Ramalho, IOP Porto, THA Lima… - Frontiers in …, 2014 - frontiersin.org
Human leukocyte antigen G (HLA-G) belongs to the family of non-classical HLA class I
genes, located within the major histocompatibility complex (MHC). HLA-G has been the …

HLA Class Ib-receptor interactions during embryo implantation and early pregnancy

LL Nilsson, TVF Hviid - Human Reproduction Update, 2022 - academic.oup.com
BACKGROUND Although the immune system intuitively must have an important role in
embryo implantation and in the achievement of a pregnancy, the molecular details have for …

Role of HLA-G in viral infections

S Jasinski-Bergner, D Schmiedel… - Frontiers in …, 2022 - frontiersin.org
The human leukocyte antigen (HLA)-G is a non-classical HLA class I molecule, which has
distinct features to classical HLA-A,-B,-C antigens, such as a low polymorphism, different …

HLA class I molecules as immune checkpoints for NK cell alloreactivity and anti-viral immunity in kidney transplantation

B Duygu, TI Olieslagers, M Groeneweg… - Frontiers in …, 2021 - frontiersin.org
Natural killer (NK) cells are innate lymphocytes that can kill diseased-or virally-infected cells,
mediate antibody dependent cytotoxicity and produce type I immune-associated cytokines …

New insights into HLA‐G mediated tolerance

G Amodio, R Sales de Albuquerque… - Tissue Antigens, 2014 - Wiley Online Library
Abstract Human Leukocyte Antigen G (HLA‐G) is a nonclassical HLA class I molecule with
well‐characterized immunomodulatory activities. HLA‐G was first described as a regulatory …

The role of HLA-G in tumor escape: manipulating the phenotype and function of immune cells

L Liu, L Wang, L Zhao, C He, G Wang - Frontiers in Oncology, 2020 - frontiersin.org
Human leukocyte antigen-G (HLA-G) is a non-classical major histocompatibility complex
class I (MHC I) molecule, and under physiological conditions, its expression is strictly …

HLA class Ib in pregnancy and pregnancy-related disorders

G Persson, WN Melsted, LL Nilsson, TVF Hviid - Immunogenetics, 2017 - Springer
The HLA class Ib genes, HLA-E, HLA-F, and HLA-G, were discovered long after the classical
HLA class Ia genes. The elucidation of their functions had a modest beginning. However …