Inflammatory monocytes and tissue-resident macrophages are key regulators of tissue
repair, regeneration, and fibrosis. After tissue injury, monocytes and macrophages undergo …

In chronic infections and cancer, T cells are exposed to persistent antigen and/or
inflammatory signals. This scenario is often associated with the deterioration of T cell …

Abstract Purpose: Hyperprogression (HP), a paradoxical boost in tumor growth, was
described in a subset of patients treated with immune checkpoint inhibitors (ICI). Neither …

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections
and cancers in animal models and humans. Tex cells are characterized by progressive loss …

Macrophages regulate tissue regeneration following injury. They can worsen tissue injury by
producing reactive oxygen species and other toxic mediators that disrupt cell metabolism …

Advanced hepatocellular carcinoma (HCC) is a serious therapeutic challenge and targeted
therapies only provide a modest benefit in terms of overall survival. Novel approaches are …

The anti‐inflammatory master regulator IL‐10 is critical to protect the host from tissue
damage during acute phases of immune responses. This regulatory mechanism, central to T …

Dysfunctional T cells can render the immune system unable to eliminate infections and
cancer. Therapeutic targeting of the surface receptors that inhibit T cell function has begun to …

T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections
and cancer. It is defined by poor effector function, sustained expression of inhibitory …

Conventional radiotherapy, in addition to its well-established tumoricidal effects, can also
activate the host immune system. Radiation therapy modulates tumour phenotypes …