The role of microRNAs in multidrug resistance of glioblastoma

P Mahinfar, B Mansoori, D Rostamzadeh, B Baradaran… - Cancers, 2022 - mdpi.com
Simple Summary Glioblastoma (GBM) is one of the most malignant types of central nervous
system tumor which accounts for more than 60% of all brain tumors in adults. Owing to poor …

miRNA-148b and its role in various cancers

N Dorraki, ZN Ghale-Noie, NS Ahmadi, V Keyvani… - …, 2021 - Taylor & Francis
miRNA-148b belongs to the family miR-148/-152, with significant differences in nonseed
sequences, which can target diverse mRNA molecules. Reportedly, it may undergo …

A promising way to overcome temozolomide resistance through inhibition of protein neddylation in glioblastoma cell lines

B Brandt, M Németh, G Berta, M Szünstein… - International journal of …, 2023 - mdpi.com
There is no effective therapy for the lately increased incidence of glioblastoma multiforme
(GBM)—the most common primary brain tumor characterized by a high degree of …

[HTML][HTML] MicroRNAs in adult high-grade gliomas: Mechanisms of chemotherapeutic resistance and their clinical relevance

Y Jegathesan, PP Stephen, ISEE Sati… - Biomedicine & …, 2024 - Elsevier
Notorious for its high mortality rate, the current standard treatment for high-grade gliomas
remains a challenge. This is largely due to the complex heterogeneity of the tumour coupled …

Magnetic and fluorescent dual-labeled genetically encoded targeted nanoparticles for malignant glioma cell tracking and drug delivery

AN Gabashvili, NS Chmelyuk, VV Oda, MK Leonova… - Pharmaceutics, 2023 - mdpi.com
Human glioblastoma multiforme (GBM) is a primary malignant brain tumor, a radically
incurable disease characterized by rapid growth resistance to classical therapies, with a …

Targeted glioma therapy—clinical trials and future directions

A Shikalov, I Koman, NM Kogan - Pharmaceutics, 2024 - mdpi.com
Glioblastoma multiforme (GBM) is the most common type of glioma, with a median survival of
14.6 months post-diagnosis. Understanding the molecular profile of such tumors allowed the …

[HTML][HTML] Transport of nanocarriers to brain for treatment of glioblastoma multiforme: Routes and challenges

S Trivedi, V Bhoyar, N Akojwar, V Belgamwar - Nano Trends, 2023 - Elsevier
Glioblastoma Multiforme (GBM) is one of the most infiltrative, heterogenous types of brain
malignancies and is mainly associated with poor prognosis. Despite various advances in …

Anticancer effect of cathelicidin LL-37, protegrin PG-1, nerve growth factor NGF, and temozolomide: impact on the mitochondrial metabolism, clonogenic potential, and …

AN Chernov, TA Filatenkova, RI Glushakov… - Molecules, 2022 - mdpi.com
Glioblastoma (GBM) is one of the most aggressive and lethal malignancy of the central
nervous system. Temozolomide is the standard of care for gliomas, frequently results in …

A Window of Opportunity to Overcome Therapeutic Failure in Neuro-Oncology.

MA Vogelbaum, G Li, AB Heimberger… - American Society of …, 2022 - europepmc.org
Glioblastoma is the most common primary malignant brain neoplasm and it remains one of
the most difficult-to-treat human cancers despite decades of discovery and translational and …

Metal-based nanostructured therapeutic strategies for glioblastoma treatment—an update

AM Gawel, R Singh, W Debinski - Biomedicines, 2022 - mdpi.com
Glioblastoma (GBM) is the most commonly diagnosed and most lethal primary malignant
brain tumor in adults. Standard treatments are ineffective, and despite promising results …