Butyrylcholinesterase in lipid metabolism: A new outlook

M Gok, C Cicek, E Bodur - Journal of neurochemistry, 2024 - Wiley Online Library
Cholinesterase enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are
traditionally associated with the termination of acetylcholine mediated neural signaling. The …

Sustainable drug discovery of multi-target-directed ligands for Alzheimer's disease

M Rossi, M Freschi… - Journal of medicinal …, 2021 - ACS Publications
The multifactorial nature of Alzheimer's disease (AD) is a reason for the lack of effective
drugs as well as a basis for the development of “multi-target-directed ligands”(MTDLs). As …

Conformational stability and denaturation processes of proteins investigated by electrophoresis under extreme conditions

P Masson, S Lushchekina - Molecules, 2022 - mdpi.com
The functional structure of proteins results from marginally stable folded conformations.
Reversible unfolding, irreversible denaturation, and deterioration can be caused by …

Fluorescent determination of butyrylcholinesterase activity and its application in biological imaging and pesticide residue detection

Q Zhang, C Fu, X Guo, J Gao, P Zhang, C Ding - ACS sensors, 2021 - ACS Publications
Butyrylcholinesterase (BChE) is an essential human cholinesterase relevant to liver
conditions and neurodegenerative diseases, which makes it a pivotal biomarker of health. It …

Highly potent and selective butyrylcholinesterase inhibitors for cognitive improvement and neuroprotection

Q Li, Y Chen, S Xing, Q Liao, B Xiong… - Journal of medicinal …, 2021 - ACS Publications
Butyrylcholinesterase (BChE) has been considered as a potential therapeutic target for
Alzheimer's disease (AD) because of its compensation capacity to hydrolyze acetylcholine …

AND-logic strategy for accurate analysis of Alzheimer's disease via fluorescent probe lighted up by two specific biomarkers

P Zhang, C Fu, H Liu, X Guo, Q Zhang, J Gao… - Analytical …, 2021 - ACS Publications
Alzheimer's disease (AD) has become a global threat to the elderly health with a short
survival time after diagnosis. Due to the asymptomatic stage during the early development …

Novel cannabidiol− carbamate hybrids as selective BuChE inhibitors: Docking-based fragment reassembly for the development of potential therapeutic agents against …

X Jiang, Z Zhang, J Zuo, C Wu, L Zha, Y Xu… - European journal of …, 2021 - Elsevier
Cannabidiol (CBD) and rivastigmine have been launched as drugs for treating dementia
and cholinesterases (ChEs) are ideal drug targets. This study focused on developing novel …

N-Benzyl Benzamide Derivatives as Selective Sub-Nanomolar Butyrylcholinesterase Inhibitors for Possible Treatment in Advanced Alzheimer's Disease

C Du, L Wang, Q Guan, H Yang, T Chen… - Journal of Medicinal …, 2022 - ACS Publications
Herein, we report a series of selective sub-nanomolar inhibitors against
butyrylcholinesterase (BChE). These compounds, bearing a novel N-benzyl benzamide …

Dual-mode ratiometric electrochemical and turn-on fluorescent detection of butyrylcholinesterase utilizing a single probe for the diagnosis of Alzheimer's disease

H Dong, L Zhao, T Wang, Y Chen, W Hao… - Analytical …, 2023 - ACS Publications
Biomarkers detection in blood with high accuracy is crucial for the diagnosis and treatment
of many diseases. In this study, the proof-of-concept fabrication of a dual-mode sensor …

Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's …

P Spatz, SAM Steinmüller, A Tutov… - Journal of Medicinal …, 2023 - ACS Publications
We present the synthesis and characterization of merged human butyrylcholinesterase (h
BChE) inhibitor/cannabinoid receptor 2 (h CB2R) ligands for the treatment of …