Cholinesterase enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are
traditionally associated with the termination of acetylcholine mediated neural signaling. The …

The multifactorial nature of Alzheimer's disease (AD) is a reason for the lack of effective
drugs as well as a basis for the development of “multi-target-directed ligands”(MTDLs). As …

The functional structure of proteins results from marginally stable folded conformations.
Reversible unfolding, irreversible denaturation, and deterioration can be caused by …

Butyrylcholinesterase (BChE) is an essential human cholinesterase relevant to liver
conditions and neurodegenerative diseases, which makes it a pivotal biomarker of health. It …

Butyrylcholinesterase (BChE) has been considered as a potential therapeutic target for
Alzheimer's disease (AD) because of its compensation capacity to hydrolyze acetylcholine …

Alzheimer's disease (AD) has become a global threat to the elderly health with a short
survival time after diagnosis. Due to the asymptomatic stage during the early development …

Cannabidiol (CBD) and rivastigmine have been launched as drugs for treating dementia
and cholinesterases (ChEs) are ideal drug targets. This study focused on developing novel …

Herein, we report a series of selective sub-nanomolar inhibitors against
butyrylcholinesterase (BChE). These compounds, bearing a novel N-benzyl benzamide …

Biomarkers detection in blood with high accuracy is crucial for the diagnosis and treatment
of many diseases. In this study, the proof-of-concept fabrication of a dual-mode sensor …

We present the synthesis and characterization of merged human butyrylcholinesterase (h
BChE) inhibitor/cannabinoid receptor 2 (h CB2R) ligands for the treatment of …