Proteolysis targeting chimera (PROTAC) technology has become a powerful strategy in drug
discovery, especially for undruggable targets/proteins. A typical PROTAC degrader consists …

Urolithin A (UA) is a naturally occurring compound derived from the metabolism of gut
microbiota, which has attracted considerable research attention due to its pharmacological …

Non-obstructive azoospermia (NOA) is a serious cause of male infertility. The Sertoli cell
responds to androgens and takes on roles supporting spermatogenesis, which may cause …

Background Ascaris lumbricoides causes human ascariasis, the most prevalent helminth
disease, infecting approximately 1 billion individuals globally. In 2019 the global disease …

Meiosis is a form of cell division that is essential to sexually reproducing organisms and is
therefore highly regulated. Each event of meiosis must occur at the correct developmental …

Background Spermatogenesis accompanied by self-renewal and differentiation of
spermatogonia under complicated regulation is crucial for male fertility. Our previous study …

Hepatocellular carcinoma (HCC) is a major global public health concern, with approximately
79 million new cases and 75 million HCC-related deaths occurring annually worldwide …

F-box proteins play essential roles in various cellular processes of spermatogenesis by
means of ubiquitylation and subsequent target protein degradation. They are the substrate …

Although, it is well understood that sperm DNA damage is associated with infertility, the
molecular details of how damaged sperm DNA affects fertility are not fully elucidated. Since …

Spermatogenesis is a highly specialized process of cell proliferation and differentiation
leading to the production of spermatozoa from spermatogonial stem cells. Due to its …