Role of LOX-1 (lectin-like oxidized low-density lipoprotein receptor 1) as a cardiovascular risk predictor: mechanistic insight and potential clinical use

J Barreto, SK Karathanasis, A Remaley… - … , and vascular biology, 2021 - Am Heart Assoc
Atherosclerosis, the underlying cause of cardiovascular disease (CVD), is a worldwide
cause of morbidity and mortality. Reducing ApoB-containing lipoproteins—chiefly, LDL (low …

[HTML][HTML] Oxidized LDL and NO synthesis—Biomarkers of endothelial dysfunction and ageing

D Gradinaru, C Borsa, C Ionescu, GI Prada - Mechanisms of ageing and …, 2015 - Elsevier
Oxidized LDL (oxLDL) and nitric oxide (NO) exert contradictory actions within the vascular
endothelium microenvironment influencing key events in atherogenesis. OxLDL and NO are …

[HTML][HTML] Atherosclerotic cardiovascular disease risk assessment: An American Society for Preventive Cardiology clinical practice statement

ND Wong, MJ Budoff, K Ferdinand, IM Graham… - American journal of …, 2022 - Elsevier
Risk for atherosclerotic cardiovascular disease (ASCVD) shows considerable heterogeneity
both in generally healthy persons and in those with known ASCVD. The foundation of …

The mannose receptor: from endocytic receptor and biomarker to regulator of (meta) inflammation

HJP van der Zande, D Nitsche, L Schlautmann… - Frontiers in …, 2021 - frontiersin.org
The mannose receptor is a member of the C-type lectin (CLEC) family, which can bind and
internalize a variety of endogenous and pathogen-associated ligands. Because of these …

High levels of soluble lectinlike oxidized low‐density lipoprotein receptor‐1 are associated with carotid plaque inflammation and increased risk of ischemic stroke

H Markstad, A Edsfeldt, I Yao Mattison… - Journal of the …, 2019 - Am Heart Assoc
Background When the lectinlike oxidized low‐density lipoprotein (ox LDL) receptor‐1 (LOX‐
1), a scavenger receptor for ox LDL, binds ox LDL, processes leading to endothelial …

Soluble LOX‐1: a novel biomarker in patients with coronary artery disease, stroke, and acute aortic dissection?

A Hofmann, C Brunssen, S Wolk, C Reeps… - Journal of the …, 2020 - Am Heart Assoc
Cardiovascular diseases are the leading cause of death worldwide. Approximately 85% of
all deaths from cardiovascular disease are due to acute myocardial infarction (AMI) and …

Lectin‐like oxidized low‐density lipoprotein receptor 1 inhibition in type 2 diabetes: phase 1 results

AL Vavere, M Sinsakul, EL Ongstad… - Journal of the …, 2023 - Am Heart Assoc
Background Blockade of the lectin‐like oxidized low‐density lipoprotein receptor‐1 (LOX‐1)
is a potentially attractive mechanism for lowering inflammatory and lipid risk in patients with …

Soluble lectin‐like oxidized low density lipoprotein receptor‐1 as a biochemical marker for atherosclerosis‐related diseases

A Pirillo, AL Catapano - Disease markers, 2013 - Wiley Online Library
Lectin‐like oxidized low density lipoprotein receptor‐1 (LOX‐1), the main oxidized low‐
density lipoprotein (OxLDL) in endothelial cells, is upregulated in atherosclerotic lesions and …

LOX-1 and atherosclerotic-related diseases

P Jin, S Cong - Clinica chimica acta, 2019 - Elsevier
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), a scavenger receptor of
oxidized low-density lipoprotein (ox-LDL) found in various cells, plays a crucial role in the …

Increased levels of lectin‐like oxidized low‐density lipoprotein receptor‐1 in ischemic stroke and transient ischemic attack

T Skarpengland, M Skjelland, XY Kong… - Journal of the …, 2018 - Am Heart Assoc
Background Soluble lectin‐like oxidized low‐density lipoprotein receptor‐1 (sLOX‐1) has
been shown to be increased in patients with acute ischemic stroke. Here, we evaluated …