The gut microbiome in Alzheimer's disease: what we know and what remains to be explored
Abstract Alzheimer's disease (AD), the most common cause of dementia, results in a
sustained decline in cognition. There are currently few effective disease modifying therapies …
sustained decline in cognition. There are currently few effective disease modifying therapies …
Circadian rhythms and astrocytes: the good, the bad, and the ugly
MH Hastings, M Brancaccio… - Annual review of …, 2023 - annualreviews.org
This review explores the interface between circadian timekeeping and the regulation of
brain function by astrocytes. Although astrocytes regulate neuronal activity across many time …
brain function by astrocytes. Although astrocytes regulate neuronal activity across many time …
[HTML][HTML] Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer's disease
DS Whittaker, L Akhmetova, D Carlin, H Romero… - Cell metabolism, 2023 - cell.com
Circadian disruptions impact nearly all people with Alzheimer's disease (AD), emphasizing
both their potential role in pathology and the critical need to investigate the therapeutic …
both their potential role in pathology and the critical need to investigate the therapeutic …
Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer's disease model
Background Alzheimer's disease (AD) patients exhibit memory disruptions and profound
sleep disturbances, including disruption of deep non-rapid eye movement (NREM) sleep …
sleep disturbances, including disruption of deep non-rapid eye movement (NREM) sleep …
Circadian regulation in aging: Implications for spaceflight and life on earth
Alterations in the circadian system are characteristic of aging on Earth. With the decline in
physiological processes due to aging, several health concerns including vision loss …
physiological processes due to aging, several health concerns including vision loss …
Dysfunction of circadian and sleep rhythms in the early stages of Alzheimer's disease
Dysfunction of circadian and sleep rhythms is an early feature of many neurodegenerative
diseases. Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in …
diseases. Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in …
Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer's disease
Failed proteostasis is a well-documented feature of Alzheimer's disease, particularly,
reduced protein degradation and clearance. However, the contribution of failed proteostasis …
reduced protein degradation and clearance. However, the contribution of failed proteostasis …
[HTML][HTML] The effects of time-restricted eating on sleep, cognitive decline, and Alzheimer's disease
A Ezzati, VM Pak - Experimental Gerontology, 2023 - Elsevier
Abstract According to the United Nations, by 2050, one in six individuals will be over age 65
globally, and one in four people would be aged 65 and older in western countries. The …
globally, and one in four people would be aged 65 and older in western countries. The …
Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models
Tauopathies, a group of neurodegenerative diseases that includes Alzheimer's disease,
commonly lead to disturbances in sleep-wake patterns and circadian rhythm disorders. The …
commonly lead to disturbances in sleep-wake patterns and circadian rhythm disorders. The …
Potential neural substrates underlying circadian and olfactory disruptions in preclinical Alzheimer's disease
QL Jeffs, JF Prather, WD Todd - Frontiers in neuroscience, 2023 - frontiersin.org
Alzheimer's disease (AD) is the leading cause of dementia, with over 45 million patients
worldwide, and poses significant economic and emotional burdens to both patients and …
worldwide, and poses significant economic and emotional burdens to both patients and …