A half-century of research on tuberculosis: Successes and challenges

BR Bloom - Journal of Experimental Medicine, 2023 - rupress.org
Great progress has been made over the past half-century, but TB remains a formidable
global health problem, particularly in low-and middle-income countries. Understanding the …

Mapping Research Trends of Medications for Multidrug-Resistant Pulmonary Tuberculosis Based on the Co-Occurrence of Specific Semantic Types in the MeSH Tree …

S Xu, Y Fu, D Xu, S Han, M Wu, X Ju, M Liu… - Drug Design …, 2023 - Taylor & Francis
Background Before the COVID-19 pandemic, tuberculosis is the leading cause of death from
a single infectious agent worldwide for the past 30 years. Progress in the control of …

Discovery and characterization of antimycobacterial nitro-containing compounds with distinct mechanisms of action and in vivo efficacy

IE Eke, JT Williams, ER Haiderer… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Nitro-containing compounds have emerged as important agents in the control of
tuberculosis (TB). From a whole-cell high-throughput screen for Mycobacterium tuberculosis …

Drug-resistant Mycobacterium tuberculosis

HIM Boshoff, DF Warner, B Gold - Frontiers in Cellular and Infection …, 2023 - frontiersin.org
Tuberculosis (TB) is anticipated to regain its position as the leading cause of death globally
due to an infectious agent, having transiently ceded that dubious accolade to SARS-CoV …

SK-03-92 Drug Kills Intracellular Mycobacterium tuberculosis

WR Schwan - Antibiotics, 2023 - mdpi.com
Background: Tuberculosis affects millions of people worldwide. The emergence of drug-
resistant Mycobacterium tuberculosis strains has made treatment more difficult. A drug …

[HTML][HTML] Breaking barriers: The potential of nanosystems in antituberculosis therapy

CSC Canales, JIM Cazorla, RMM Cazorla… - Bioactive Materials, 2024 - Elsevier
Tuberculosis (TB), caused by Mycobacterium tuberculosis, continues to pose a significant
threat to global health. The resilience of TB is amplified by a myriad of physical, biological …

Advances in computational frameworks in the fight against TB: The way forward

A Naidu, SS Nayak, S Lulu S… - Frontiers in …, 2023 - frontiersin.org
Around 1.6 million people lost their life to Tuberculosis in 2021 according to WHO estimates.
Although an intensive treatment plan exists against the causal agent, Mycobacterium …

[PDF][PDF] 温州市耐多药/利福平耐药结核分枝杆菌耐药基因突变及特征分析

吴联朋, 徐克, 何贵清 - Journal of Wenzhou Medical University, 2023 - xb.wmu.edu.cn
目的: 通过全基因组测序(WGS) 分析温州市耐多药/利福平耐药结核分枝杆菌(MDR/RR-MTB)
的耐药情况, 为耐药结核病的防治提供参考依据. 方法: 收集2021 年1 月至2022 年9 …

Occurrence and dissemination of antibiotics and antibiotic resistance in aquatic environment and its ecological implications: a review

A Singh, SG Pratap, A Raj - Environmental Science and Pollution …, 2024 - Springer
The occurrence of antibiotics and antibiotic-resistant bacteria (ARBs), genes (ARGs), and
mobile genetic elements (MGEs) in aquatic systems is growing global public health concern …

Synthesis, structures, reactivity and medicinal chemistry of antitubercular benzothiazinones

RW Seidel, A Richter, R Goddard… - Chemical …, 2023 - pubs.rsc.org
Tuberculosis is the leading bacterial killer worldwide. 8-Nitro-4H-benzo [e][1, 3] thiazin-4-
ones are a potent class of antitubercular agents with a new mechanism of action. BTZ043 …