Intact and N-or C-terminal end truncated AQP0 function as open water channels and cell-to-cell adhesion proteins: end truncation could be a prelude for adjusting the …
SS Kumari, K Varadaraj - Biochimica et Biophysica Acta (BBA)-General …, 2014 - Elsevier
Background Investigate the impact of natural N-or C-terminal post-translational truncations
of lens mature fiber cell Aquaporin 0 (AQP0) on water permeability (Pw) and cell-to-cell …
of lens mature fiber cell Aquaporin 0 (AQP0) on water permeability (Pw) and cell-to-cell …
[HTML][HTML] Aquaporin 0 modulates lens gap junctions in the presence of lens-specific beaded filament proteins
S Kumari, J Gao, RT Mathias, X Sun… - … & Visual Science, 2017 - iovs.arvojournals.org
Purpose: The objective of this study was to understand the molecular and physiologic
mechanisms behind the lens cataract differences in Aquaporin 0-knockout-Heterozygous …
mechanisms behind the lens cataract differences in Aquaporin 0-knockout-Heterozygous …
[HTML][HTML] Aquaporins in the Cornea
S Melnyk, WB Bollag - International Journal of Molecular Sciences, 2024 - mdpi.com
The cornea is an avascular, transparent tissue that allows light to enter the visual system.
Accurate vision requires proper maintenance of the cornea's integrity and structure. Due to …
Accurate vision requires proper maintenance of the cornea's integrity and structure. Due to …
[HTML][HTML] Increased aquaporin 1 and 5 membrane expression in the lens epithelium of cataract patients
O Barandika, M Ezquerra-Inchausti… - … et Biophysica Acta (BBA …, 2016 - Elsevier
In this work we have analyzed the expression levels of the main aquaporins (AQPs)
expressed in human lens epithelial cells (HLECs) using 112 samples from patients treated …
expressed in human lens epithelial cells (HLECs) using 112 samples from patients treated …
A systematic review on cornea epithelial-stromal homeostasis
HL Wong, SHL Poon, Y Bu, ACY Lo, V Jhanji… - Ophthalmic …, 2021 - karger.com
Introduction: This review aims to summarise the role of different cells, genes, proteins and
lipid in regulating cornea epithelial-stromal homeostasis. Methods: We performed an Entrez …
lipid in regulating cornea epithelial-stromal homeostasis. Methods: We performed an Entrez …
Effect of hydrogen peroxide on lens transparency, intracellular pH, gap junction coupling, hydrostatic pressure and membrane water permeability
K Varadaraj, J Gao, RT Mathias, S Kumari - Experimental Eye Research, 2024 - Elsevier
Clouding of the eye lens or cataract is an age-related anomaly that affects middle-aged
humans. Exploration of the etiology points to a great extent to oxidative stress due to …
humans. Exploration of the etiology points to a great extent to oxidative stress due to …
AQP5 deficiency promotes the senescence of lens epithelial cells through mitochondrial dysfunction
K Zhang, G Di, B Li, H Ge, Y Bai, W Bian… - Biochemical and …, 2023 - Elsevier
Cataract is lens opacity, which is a common blinding eye disease worldwide. Aquaporin 5
(AQP5) is expressed in the human and mouse lenses. This study aimed to investigate the …
(AQP5) is expressed in the human and mouse lenses. This study aimed to investigate the …
[HTML][HTML] Chlorpheniramine attenuates histamine-mediated aquaporin 5 downregulation in human nasal epithelial cells via suppression of NF-κB activation
YL Chang, CS Lin, HW Wang, KR Jian… - International journal of …, 2017 - ncbi.nlm.nih.gov
Background: Aquaporin 5 (AQP5) is most likely the primary water channel in the human
nasal mucosa and acts as a key tight junction protein. The signaling cascades responsible …
nasal mucosa and acts as a key tight junction protein. The signaling cascades responsible …
Aquaporin 5 in the eye: Expression, function, and roles in ocular diseases
K Zhang, G Di, Y Bai, A Liu, W Bian, P Chen - Experimental Eye Research, 2023 - Elsevier
As a water channel protein, aquaporin 5 (AQP5) is essential for the maintenance of the
normal physiological functions of ocular tissues. This review provides an overview of the …
normal physiological functions of ocular tissues. This review provides an overview of the …
[HTML][HTML] C-terminal end of Aquaporin 0 regulates lens gap junction channel function
K Varadaraj, J Gao, RT Mathias… - … Ophthalmology & Visual …, 2019 - tvst.arvojournals.org
Purpose: We reported previously that aquaporin 0 (AQP0) modulates lens fiber cell gap
junction (GJ) channel function. The present study was conducted to find out whether the C …
junction (GJ) channel function. The present study was conducted to find out whether the C …