Aneuploidy in mammalian oocytes and the impact of maternal ageing

C Charalambous, A Webster, M Schuh - Nature Reviews Molecular Cell …, 2023 - nature.com
During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

[HTML][HTML] The biochemistry and effectiveness of antioxidants in food, fruits, and marine algae

LL Pruteanu, DS Bailey, AC Grădinaru, L Jäntschi - Antioxidants, 2023 - mdpi.com
It is more effective to maintain good health than to regain it after losing it. This work focuses
on the biochemical defense mechanisms against free radicals and their role in building and …

Hormones and aging: an endocrine society scientific statement

AR Cappola, RJ Auchus… - The Journal of …, 2023 - academic.oup.com
Multiple changes occur across various endocrine systems as an individual ages. The
understanding of the factors that cause age-related changes and how they should be …

[HTML][HTML] Aging-related ovarian failure and infertility: melatonin to the rescue

RJ Reiter, R Sharma, A Romero, W Manucha, DX Tan… - Antioxidants, 2023 - mdpi.com
Aging has a major detrimental effect on the optimal function of the ovary with changes in this
organ preceding the age-related deterioration in other tissues, with the middle-aged …

[HTML][HTML] Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes-A narrative review

E Esencan, G Beroukhim, DB Seifer - Reproductive biology and …, 2022 - Springer
Reproductive aging is characterized by a decline in oocyte quantity and quality, which is
directly associated with a decline in reproductive potential, as well as poorer reproductive …

[HTML][HTML] The role of mitochondria in human fertility and early embryo development: what can we learn for clinical application of assessing and improving mitochondrial …

A Podolak, I Woclawek-Potocka, K Lukaszuk - Cells, 2022 - mdpi.com
Mitochondria are well known as 'the powerhouses of the cell'. Indeed, their major role is
cellular energy production driven by both mitochondrial and nuclear DNA. Such a feature …

[HTML][HTML] Effects of heat stress on bovine oocytes and early embryonic development—an update

K Miętkiewska, P Kordowitzki, CS Pareek - Cells, 2022 - mdpi.com
Heat stress is a major threat to cattle reproduction today. It has been shown that the effect of
high temperature not only has a negative effect on the hormonal balance, but also directly …

[HTML][HTML] Mitoquinone shifts energy metabolism to reduce ROS-induced oxeiptosis in female granulosa cells and mouse oocytes

KH Tsui, CJ Li - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
The female reproductive system is quite sensitive to regulation, and external environmental
stimuli may cause oxidative stress which in turn may lead to accelerated aging and …

Telomeres, cellular senescence, and aging: past and future

M Eppard, JF Passos, S Victorelli - Biogerontology, 2024 - Springer
Over half a century has passed since Alexey Olovnikov's groundbreaking proposal of the
end-replication problem in 1971, laying the foundation for our understanding of telomeres …

[HTML][HTML] Relevance of vitamin D and its deficiency for the ovarian follicle and the oocyte: an update

A Grzeczka, S Graczyk, A Skowronska, MT Skowronski… - Nutrients, 2022 - mdpi.com
For many years, vitamin D (VD) has been known to be an essential micronutrient with
important relevance not only for the skeletal system, but also for numerous other mammalian …