Illicitly manufactured fentanyl (IMF) is a significant contributor to the increasing rates of
overdose-related deaths. Its high potency and lipophilicity can complicate opioid withdrawal …

Introduction Misuse of prescription and synthetic opioids is a primary contributor to the
escalating overdose crisis in North America. However, factors associated with nonfatal …

Background Prescription-type opioid use disorder (POUD) is often accompanied by
comorbid anxiety, yet the impact of anxiety on retention in opioid agonist therapy (OAT) is …

Abstract Background The United States continues to experience unprecedented rates of
overdose mortality and need to identify effective policies or practices that can be …

Introduction Conflictual evidence exists regarding the effects of cannabis use on the
outcomes of opioid agonist therapy (OAT). In this exploratory analysis, we examined the …

Buprenorphine has been successfully used for decades in the treatment of opioid use
disorder, yet there are complexities to its use that warrant attention to maximize its utility …

Over the past several decades, rising rates of opioid overdose mortality in North America
have underscored the importance of finding effective and safe treatment strategies to …

Background: The vast majority of accidental opioid toxicity deaths in Canada were fentanyl-
related in 2022. The strongest evidence-based treatment defense against such deaths is …

Abstract Background and Objectives Although concurrent stimulant use is common among
people with opioid use disorder (OUD), there is little evidence on its impacts on opioid …

Abstract Background: North America is facing an opioid epidemic primarily attributable to
potent synthetic opioids. There has been a marked increase in methamphetamine …