Long non‐coding RNA s as an epigenetic regulator in human cancers

Y Kondo, K Shinjo, K Katsushima - Cancer science, 2017 - Wiley Online Library
Recent studies have described the important multiple roles of long non‐coding RNA s (lnc
RNA s) during oncogenic transformation. Because the coding genome accounts for a small …

[HTML][HTML] Long non-coding RNAs: Mechanism of action and functional utility

SA Bhat, SM Ahmad, PT Mumtaz, AA Malik… - Non-coding RNA …, 2016 - Elsevier
Recent RNA sequencing studies have revealed that most of the human genome is
transcribed, but very little of the total transcriptomes has the ability to encode proteins. Long …

[HTML][HTML] Circular RNA has_circ_0067934 is upregulated in esophageal squamous cell carcinoma and promoted proliferation

W Xia, M Qiu, R Chen, S Wang, X Leng, J Wang… - Scientific reports, 2016 - nature.com
Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent and deadly
types of cancer worldwide especially in Eastern Asia and the prognosis of ESCC remain …

[HTML][HTML] The role of epigenetic modifications in human cancers and the use of natural compounds as epidrugs: Mechanistic pathways and pharmacodynamic actions

A Bouyahya, H Mechchate, L Oumeslakht, I Zeouk… - Biomolecules, 2022 - mdpi.com
Cancer is a complex disease resulting from the genetic and epigenetic disruption of normal
cells. The mechanistic understanding of the pathways involved in tumor transformation has …

[HTML][HTML] Long non-coding RNA TUG1 is up-regulated in hepatocellular carcinoma and promotes cell growth and apoptosis by epigenetically silencing of KLF2

MD Huang, WM Chen, FZ Qi, M Sun, TP Xu, P Ma… - Molecular cancer, 2015 - Springer
Background Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related
death worldwide, and the biology of this cancer remains poorly understood. Recent …

TUG 1: a pivotal oncogenic long non‐coding RNA of human cancers

Z Li, J Shen, MTV Chan, WKK Wu - Cell proliferation, 2016 - Wiley Online Library
Long non‐coding RNA s (lnc RNA s) are a group greater than 200 nucleotides in length. An
increasing number of studies has shown that lnc RNA s play important roles in diverse …

[HTML][HTML] Long non-coding RNAs: potential new biomarkers for predicting tumor invasion and metastasis

C Jiang, X Li, H Zhao, H Liu - Molecular cancer, 2016 - Springer
Long non-coding RNAs (lncRNAs) play important roles in malignant neoplasia. Indeed,
many hallmarks of cancer define that the malignant phenotype of tumor cells are controlled …

LncRNA TUG1 acts as a tumor suppressor in human glioma by promoting cell apoptosis

J Li, M Zhang, G An, Q Ma - Experimental Biology and …, 2016 - journals.sagepub.com
Previous studies have revealed multiple functional roles of long non-coding RNA taurine
upregulated gene 1 in different types of malignant tumors, except for human glioma. Here, it …

Long non-coding RNA taurine upregulated 1 enhances tumor-induced angiogenesis through inhibiting microRNA-299 in human glioblastoma

H Cai, X Liu, J Zheng, Y Xue, J Ma, Z Li, Z Xi, M Bao… - Oncogene, 2017 - nature.com
Angiogenesis is one of the critical biological elements affecting the development and
progression of cancer. Long non-coding RNAs (lncRNAs) are important regulators and …

Long noncoding RNAs in cancer: from discovery to therapeutic targets

R Choudhari, MJ Sedano, AL Harrison… - Advances in clinical …, 2020 - Elsevier
Long noncoding RNAs (lncRNAs) have recently gained considerable attention as key
players in biological regulation; however, the mechanisms by which lncRNAs govern …