Protein phosphatase 2A (PP 2A) is a serine/threonine phosphatase involved in the
regulation of many cellular processes. A confirmed tumor suppressor protein, PP 2A is …

The progression of cancers and neurodegenerative disorders is largely defined by a set of
molecular determinants that are either complementarily deregulated, or share remarkably …

Impairment of protein phosphatases, including the family of serine/threonine phosphatases
designated PP2A, is essential for the pathogenesis of many diseases, including cancer. The …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID), autism and
schizophrenia, have high socioeconomic impact, yet poorly understood etiologies. A recent …

Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …

To identify key signaling pathways involved in ambient particulate matter (PM)-induced
pulmonary injury, we generated a mouse model with myeloid-specific deletion of Ppp2r1a …

Simple Summary GBM is a highly heterogeneous tumor owing to incredible cellular plasticity
and adaptation to hypoxia, nutrient availability and therapy. This plasticity is in part due to …

Cellular processes are dictated by the active signaling of proteins relaying messages to
regulate cell proliferation, apoptosis, signal transduction and cell communications. An …

Telomeres are repetitive nucleotide sequences at the ends of each chromosome. It has
been hypothesized that telomere attrition evolved as a tumor suppressor mechanism in …

We have mined public genomic datasets to identify genes coding for components of the
ubiquitin proteasome system (UPS) that may qualify as potential diagnostic and therapeutic …