Rational drug use in special populations is a clinical problem that doctors and pharma-cists
must consider seriously. Neonates are the most physiologically immature and vulnerable to …

Introduction There is a need for structured approaches to inform on pharmacotherapy in
preterm neonates. With their proven track record up to regulatory acceptance …

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the US,
and hepatotoxicity is initiated by a reactive metabolite which induces characteristic …

To truly attain effective and safe pharmacotherapy, the similarities and dissimilarities in
physiology between micro-preemies and extreme preterm infants should be explored. The …

Background: pathophysiological changes such as low cardiac output (LCO) impact
pharmacokinetics, but its extent may be different throughout pediatrics compared to adults …

Acetaminophen is gaining importance as a first-line drug for treating patent ductus arteriosus
(PDA) in neonates. Predominant metabolites of acetaminophen in preterm neonates vary …

Paracetamol, a widely used analgesic and antipyretic drug, can be found in various
formulations and doses for both home and hospital use. The aim of this study was to …

Introduction: There is a need for structured approaches to inform on pharmacotherapy in
preterm neonates. With their proven track record up to regulatory acceptance …

Drug-induced liver injury (DILI) is a prominent health concern and a major challenge for
drug development worldwide. One of the most common causes of DILI in the developed …