Azoles are a famous and promising class of drugs for treatment of a range of ailments
especially fungal infections. A wide variety of azole derivatives are also known to exhibit …

Background/purpose Melasma is a frequent photoexacerbated hyperpigmentary disorder,
which can significantly impact on the quality of life. We sought to review the pathogenesis of …

With an increasing number of multicultural patients and those of different backgrounds
presenting in dermatology clinics, issues facing patients with higher Fitzpatrick skin …

The known derivatives from hydroquinone, α and β-arbutin, are used as depigmenting
agents. In this work, we demonstrate that the oxy form of tyrosinase (oxytyrosinase) …

Studies on the discovery of tyrosinase enzyme inhibitors and exploration for better cytotoxic
agents remain an important line in drug discovery and development. A series of synthetic …

Kojic acid (KA), produced mainly by Aspergillus species, is a product of fungal secondary
metabolism and has great potential in biotechnological applications. The use of KA has …

Annually, wine production is responsible for generating large quantities of residues, which
are frequently disposed of and not valorized. So far, different studies have been conducted …

Reliable measurement of the amount of melanin produced by melanocytes is essential to
study various skin disorders and to evaluate the efficacy of candidate reagents for such …

Hyperpigmentation of skin is caused by several factors. UV exposure, in addition to oxidative
stress, elevates inflammatory mediators stimulating melanogenesis. Herbal-derived …

Melanin is produced in melanocytes and stored in melanosomes, after which it is transferred
to keratinocytes and, thus, determines skin color. Despite its beneficial sun-protective effects …