The advancing validation and exploitation of CSF and blood neurofilament light chain
protein as a biomarker of neuroaxonal damage has deeply changed the current diagnostic …

Neurodegenerative disorders (NDDs) are caused by progressive loss of functional neurons
following the aggregation and fibrillation of proteins in the central nervous system. The …

The kynurenine pathway is implicated in aging, longevity, and immune regulation, but
longitudinal studies and assessment of the cerebrospinal fluid (CSF) are lacking. We …

Purpose We aimed to investigate the relevance of body mass index (BMI) to postoperative
delirium (POD), and to test whether the influences of BMI on POD were mediated by …

Background: Aerobic exercise is proposed to attenuate cognitive decline in aging. We
investigated the effect of different aerobic exercise interventions and cardiorespiratory …

It is unclear whether cerebrospinal fluid (CSF) biomarkers of neurodegeneration predict
brain atrophy in cognitively healthy older adults, whether these associations can be …

Introduction Fatty acid–binding protein 3 (FABP3) is a biomarker of neuronal membrane
disruption, associated with lipid dyshomeostasis—a notable Alzheimer's disease (AD) …

INTRODUCTION The kynurenine pathway's (KP) malfunction is closely related to
Alzheimer's disease (AD), for antagonistic kynurenic acid (KA) and agonistic quinolinic acid …

Memory decline is characteristic of cognitive ageing and it has been suggested that one
important factor underpinning the magnitude of age deficits is a reduction in the fidelity or …

Background: Delirium is associated with dementia and thus biomarkers reflecting
neurodegeneration are of interest. Fatty acid-binding protein 3 (FABP3) is a cytoplasmic …