There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

Caffeine is a widely recognized psychostimulant compound with a long history of
consumption by humans. While it has received a significant amount of attention there is still …

Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited
disease characterized by ventricular arrhythmias and progressive ventricular dysfunction …

Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic
polymorphic ventricular tachycardia, a condition characterized by prominent ventricular …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited
arrhythmogenic disease occurring in patients with a structurally normal heart: the disease is …

Atrial fibrillation (AF), the most common human cardiac arrhythmia, is associated with
abnormal intracellular Ca2+ handling. Diastolic Ca2+ release from the sarcoplasmic …

Cardiomyocyte T tubules are important for regulating ion flux. Bridging integrator 1 (BIN1) is
a T-tubule protein associated with calcium channel trafficking that is downregulated in failing …

Background Approximately half of patients with heart failure die suddenly as a result of
ventricular arrhythmias. Although abnormal Ca2+ release from the sarcoplasmic reticulum …

Carvedilol is one of the most effective beta blockers for preventing ventricular
tachyarrhythmias in heart failure, but the mechanisms underlying its favorable antiarrhythmic …

Triggered activity in cardiac muscle and intracellular Ca2+ have been linked in the past.
However, today not only are there a number of cellular proteins that show clear Ca2+ …