Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited cardiac
arrhythmia syndrome that often leads to sudden cardiac death. The most common form of …

In cardiac muscle cells, ryanodine receptor (RyR) mediated Ca release from the
sarcoplasmic reticulum (SR) drives the contractile apparatus. Spontaneous bouts of inter …

Inherited arrhythmia syndromes (IASs) can cause life-threatening arrhythmias and are
responsible for a significant proportion of sudden cardiac deaths (SCDs). Despite progress …

Ca2+ leak via ryanodine receptor type 2 (RyR2) can cause potentially fatal arrhythmias in a
variety of heart diseases and has also been implicated in neurodegenerative and seizure …

In response to chronic hypertension, the heart compensates by hypertrophic growth, which
frequently progresses to heart failure. Although intracellular calcium (Ca2+) has a central …

Ventricular arrhythmias are the key underlying cause of sudden cardiac death, a common
cause of mortality and a significant public health burden. Insights into the …

Cardiac voltage‐gated ion channels (VGICs) play critical roles in mediating cardiac
electrophysiological signals, such as action potentials, to maintain normal heart excitability …

Aim R y R 2 mutations are associated with catecholaminergic polymorphic tachycardia, a
condition characterized by ventricular and atrial arrhythmias. The present experiments …

Cardiac ischemia is associated with arrhythmias; however, effective therapies are currently
limited. The cardiac voltage-gated sodium channel α subunit (SCN5A), encoding the Na v …

Rationale: The recessive form of catecholaminergic polymorphic ventricular tachycardia is
caused by mutations in the cardiac calsequestrin-2 gene; this variant of catecholaminergic …