DNA methylation remains an under-recognized diagnostic biomarker for several diseases,
including neurodegenerative disorders. In this study, we examined differences in global …

Alzheimer's Disease (AD) is a major health problem worldwide. The lack of efficacy of
existing therapies for AD is because of diagnosis at late stages of the disease, limited …

Background Post‐operative cognitive dysfunction (POCD) is a decline of cognitive status
that commonly occurs after surgery in elderly patients. Whether DNA methylation is …

Epigenetic mechanisms, especially DNA methylation, are suggested to play a role in the age-
of-onset in Huntington's disease (HD) based on studies on patient brains, and cellular and …

Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disease and
clinically manifests with cognitive decline and behavioral disabilities. Over the past years …

Introduction Kidney transplantation remains the gold standard of treatment for end-stage
renal disease (ESRD), with improved patient outcomes compared with dialysis. Epigenome …

Epigenetic mechanisms might be involved in Alzheimer's disease (AD). Genetic
polymorphisms in several genes, including APOE (Apolipoprotein E), PSEN1 (Presenilin 1) …

Abstract Background Stressful life events (SLEs) are associated with hyper (re-) activity of
the HPA-axis. HPA-axis hyper (re-) activity is thought to be a major risk factor for depression …

Diet is a modifiable risk factor for cardiovascular disease (CVD) and dementia, yet relatively
little is known about the effect of a high glycemic diet (HGD) on the brain's microvasculature …

Inflammation and ageing‐related DNA methylation patterns in the blood have been linked to
a variety of morbidities, including cognitive decline and neurodegenerative disease …