Roles of circadian clocks in cancer pathogenesis and treatment

Y Lee - Experimental & molecular medicine, 2021 - nature.com
Circadian clocks are ubiquitous timing mechanisms that generate approximately 24-h
rhythms in cellular and bodily functions across nearly all living species. These internal clock …

Circadian rhythms, disease and chronotherapy

Y Lee, JM Field, A Sehgal - Journal of biological rhythms, 2021 - journals.sagepub.com
Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

The ventral tegmental area and nucleus accumbens as circadian oscillators: implications for drug abuse and substance use disorders

DD Becker-Krail, WH Walker, RJ Nelson - Frontiers in Physiology, 2022 - frontiersin.org
Circadian rhythms convergently evolved to allow for optimal synchronization of individuals'
physiological and behavioral processes with the Earth's 24-h periodic cycling of …

Circadian rhythms in cardiovascular metabolism

H Lal, SK Verma, Y Wang, M Xie… - Circulation Research, 2024 - Am Heart Assoc
Energetic demand and nutrient supply fluctuate as a function of time-of-day, in alignment
with sleep-wake and fasting-feeding cycles. These daily rhythms are mirrored by 24-hour …

The genetics of sleep disorders in children: a narrative review

G Mainieri, A Montini, A Nicotera, G Di Rosa, F Provini… - Brain Sciences, 2021 - mdpi.com
Sleep is a universal, highly preserved process, essential for human and animal life, whose
complete functions are yet to be unravelled. Familial recurrence is acknowledged for some …

Sleep patterns, eating behavior and the risk of noncommunicable diseases

S Gomes, C Ramalhete, I Ferreira, M Bicho, A Valente - Nutrients, 2023 - mdpi.com
Sleep is extremely important for the homeostasis of the organism. In recent years, various
studies have been carried out to address factors related to sleep patterns and their influence …

Sleep-related regions in neurodegenerative diseases by central nervous system localization using magnetic resonance imaging

S Mohammadi, M Mohammadi, S Ghaderi - Psychiatry Research …, 2023 - Elsevier
Sleep disruptions associated with neurodegenerative diseases (NDDs) damage the brain's
sleep-regulating regions. Advanced magnetic resonance imaging (MRI) techniques can …

Multi-modal regulation of circadian physiology by interactive features of biological clocks

Y Lee, JP Wisor - Biology, 2021 - mdpi.com
Simple Summary Circadian rhythms, driven by molecular clockwork, exist in nearly all cells
and tissues throughout the body, and these rhythmic oscillators constitute tightly coupled …

Chronic intracranial recordings in the globus pallidus reveal circadian rhythms in Parkinson's disease

JN Cagle, T de Araujo, KA Johnson, J Yu… - Nature …, 2024 - nature.com
Circadian rhythms have been shown in the subthalamic nucleus (STN) in Parkinson's
disease (PD), but only a few studies have focused on the globus pallidus internus (GPi). This …

Potential role of the circadian clock in the regulation of cancer stem cells and cancer therapy

Y Lee, AS Tanggono - International Journal of Molecular Sciences, 2022 - mdpi.com
Circadian rhythms, including sleep/wake cycles as well as hormonal, immune, metabolic,
and cell proliferation rhythms, are fundamental biological processes driven by a cellular time …