Importance Approximately 43 720 new cases of thyroid carcinoma are expected to be
diagnosed in 2023 in the US. Five-year relative survival is approximately 98.5%. This review …

Biologic and Clinical Perspectives on Thyroid Cancer | New England Journal of Medicine Skip to
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BTA_Guidelines_for_the_Management_of_Thyroid Cancer_E Page 1 CLINICAL
ENDOCRINOLOGY VOLUME 81 SUPPLEMENT 1 JULY 2014 THE CLINICAL JOURNAL OF …

Since the discovery of the RET receptor tyrosine kinase in 1985, alterations of this protein
have been found in diverse thyroid cancer subtypes. RET gene rearrangements are …

Genes in which germline mutations confer highly or moderately increased risks of cancer
are called cancer predisposition genes. More than 100 of these genes have been identified …

Disclaimer: The practice guidelines of the American College of Medical Genetics and
Genomics (ACMG) and the National Society of Genetic Counselors (NSGC) are developed …

The rearranged during transfection (RET) proto-oncogene was identified in 1985 and, very
soon thereafter, a rearrangement named RET/PTC was discovered in papillary thyroid …

The RET receptor tyrosine kinase is crucial for normal development but also contributes to
pathologies that reflect both the loss and the gain of RET function. Activation of RET occurs …

Germline inactivating mutations of isoform 4 of phosphodiesterase (PDE) 11A (coded by the
PDE11A gene) have been associated with familial adrenocortical tumors and familial …

The paraganglioma (PGL) syndromes types 1–5 are autosomal dominant disorders
characterized by familial predisposition to PGLs, phaeochromocytomas (PCs), renal cell …