A growing appreciation of the pathophysiological interrelatedness of metabolic risk factors
such as obesity and diabetes, chronic kidney disease, and cardiovascular disease has led …

Obesity is associated with the development of various complications, including diabetes,
atherosclerosis, and an increased risk for infections, driven by dysfunctional innate immune …

Background and aims Obesity predisposes to metabolic and cardiovascular diseases.
Adipose tissue inflammation and systemic inflammation contribute to these complications …

Objective Obesity and its consequences are among the biggest challenges facing the
healthcare system. Uterine leiomyomas are the most common gynecologic tumors. The risk …

The adventitia receives input signals from the vessel wall, the immune system, perivascular
nerves and from surrounding tissues to generate effector responses that regulate structural …

Abstract Purpose of Review Anti-hypertensive and lipid lowering therapy addresses only
half of the cardiovascular disease risk in patients with body mass index> 30 kg/m2, ie …

Inflammation is a crucial factor in the development and progression of cardiovascular
diseases (CVD). Cardiac remodeling in the presence of persistent inflammation leads to …

Owing to the overwhelming obesity epidemic, preserved ejection fraction heart failure
commonly ensues in patients with severe obesity and the obese phenotype of preserved …

The pharmacological inhibition of sodium-glucose cotransporter 2 (SGLT2) has emerged as
a treatment for patients with type 2 diabetes mellitus (T2DM), cardiovascular disease and/or …

The stomach-derived hormone ghrelin regulates essential physiological functions. The
ghrelin receptor (GHSR) has ligand-independent actions; therefore, GHSR gene deletion …