Recognizing the importance of childhood maltreatment as a critical factor in psychiatric diagnoses, treatment, research, prevention, and education
MH Teicher, JB Gordon, CB Nemeroff - Molecular psychiatry, 2022 - nature.com
Childhood maltreatment is the most important preventable risk factor for psychiatric
disorders. Maltreated individuals typically develop psychiatric disorders at an earlier age …
disorders. Maltreated individuals typically develop psychiatric disorders at an earlier age …
The effects of social deprivation on adolescent development and mental health
Adolescence (the stage between 10 and 24 years) is a period of life characterised by
heightened sensitivity to social stimuli and the increased need for peer interaction. The …
heightened sensitivity to social stimuli and the increased need for peer interaction. The …
Early life stress and development: potential mechanisms for adverse outcomes
Background Chronic and/or extreme stress in early life, often referred to as early adversity,
childhood trauma, or early life stress, has been associated with a wide range of adverse …
childhood trauma, or early life stress, has been associated with a wide range of adverse …
Rethinking concepts and categories for understanding the neurodevelopmental effects of childhood adversity
Discovering the processes through which early adverse experiences affect children's
nervous-system development, health, and behavior is critically important for developing …
nervous-system development, health, and behavior is critically important for developing …
Childhood unpredictability and the development of exploration
Early in development, the process of exploration helps children gather new information that
fosters learning about the world. Yet, it is unclear how childhood experiences may influence …
fosters learning about the world. Yet, it is unclear how childhood experiences may influence …
Adverse childhood experiences and adult obesity: a systematic review of plausible mechanisms and meta-analysis of cross-sectional studies
DA Wiss, TD Brewerton - Physiology & Behavior, 2020 - Elsevier
Adverse childhood experiences (ACEs) can become biologically embedded leaving a
lasting signature on multiple body systems. ACE scores have been used to associate …
lasting signature on multiple body systems. ACE scores have been used to associate …
[HTML][HTML] Acute social isolation evokes midbrain craving responses similar to hunger
L Tomova, KL Wang, T Thompson, GA Matthews… - Nature …, 2020 - nature.com
When people are forced to be isolated from each other, do they crave social interactions? To
address this question, we used functional magnetic resonance imaging to measure neural …
address this question, we used functional magnetic resonance imaging to measure neural …
Neurodevelopmental optimization after early-life adversity: cross-species studies to elucidate sensitive periods and brain mechanisms to inform early intervention
Human brain development is influenced by early-life experiences, particularly during
sensitive periods, with impact on cognitive and emotional outcomes. Understanding how the …
sensitive periods, with impact on cognitive and emotional outcomes. Understanding how the …
Early-life adversity and neurological disease: age-old questions and novel answers
Neurological illnesses, including cognitive impairment, memory decline and dementia, affect
over 50 million people worldwide, imposing a substantial burden on individuals and society …
over 50 million people worldwide, imposing a substantial burden on individuals and society …
Stress to inflammation and anhedonia: Mechanistic insights from preclinical and clinical models
Anhedonia, as evidenced by impaired pleasurable response to reward, reduced reward
motivation, and/or deficits in reward-related learning, is a common feature of depression …
motivation, and/or deficits in reward-related learning, is a common feature of depression …