Cardiovascular toxicities associated with tyrosine kinase inhibitors
Abstract Purpose of Review To provide a detailed overview of cardiovascular adverse
events associated with the use of tyrosine kinase inhibitors across different tumor types …
events associated with the use of tyrosine kinase inhibitors across different tumor types …
Mitochondrial Dysfunction in Cardiotoxicity Induced by BCR-ABL1 Tyrosine Kinase Inhibitors -Underlying Mechanisms, Detection, Potential Therapies
S Sun, J Qin, W Liao, X Gao, Z Shang, D Luo… - Cardiovascular …, 2023 - Springer
The advent of BCR-ABL tyrosine kinase inhibitors (TKIs) targeted therapy revolutionized the
treatment of chronic myeloid leukemia (CML) patients. Mitochondria are the key organelles …
treatment of chronic myeloid leukemia (CML) patients. Mitochondria are the key organelles …
Targeting HSPA8 inhibits proliferation via downregulating BCR-ABL and enhances chemosensitivity in imatinib-resistant chronic myeloid leukemia cells
Z Liu, W Zheng, Y Liu, B Zhou, Y Zhang… - Experimental Cell …, 2021 - Elsevier
The resistance to tyrosine kinase inhibitors is currently a major problem for chronic myeloid
leukemia (CML) treatment and HSPA8 is highly expressed and a hallmark of poor prognosis …
leukemia (CML) treatment and HSPA8 is highly expressed and a hallmark of poor prognosis …
The state of the art in secondary pharmacology and its impact on the safety of new medicines
RJ Brennan, S Jenkinson, A Brown… - Nature Reviews Drug …, 2024 - nature.com
Secondary pharmacology screening of investigational small-molecule drugs for potentially
adverse off-target activities has become standard practice in pharmaceutical research and …
adverse off-target activities has become standard practice in pharmaceutical research and …
[HTML][HTML] Arterial hypertension assessment in a population with chronic myeloid leukemia
R Roa-Chamorro, F Jaén-Águila, JM Puerta-Puerta… - Scientific Reports, 2021 - nature.com
Abstract Treatment of chronic myeloid leukaemia (CML) is based on tyrosine kinase
inhibitors (TKI), whose introduction in 2001 improved the survival rate after 5 years from 40 …
inhibitors (TKI), whose introduction in 2001 improved the survival rate after 5 years from 40 …
Inhibition of soluble epoxide hydrolase attenuates bosutinib-induced blood pressure elevation
Z Cui, B Li, Y Zhang, J He, X Shi, H Wang, Y Zhao… - …, 2021 - Am Heart Assoc
Endothelial cells play a critical role in maintaining homeostasis of vascular function, and
endothelial activation is involved in the initial step of atherogenesis. Previously, we reported …
endothelial activation is involved in the initial step of atherogenesis. Previously, we reported …
[HTML][HTML] Подходы к ранней диагностике и профилактике кардиоваскулярной токсичности, индуцированной таргетными препаратами и ингибиторами …
НС Мещерина, МА Степченко… - Кардиоваскулярная …, 2023 - cyberleninka.ru
Разработка и внедрение в клиническую практику таргетных препаратов и ингибиторов
контрольных точек иммунитета (ИКТИ) позволили увеличить общую и бессобытийную …
контрольных точек иммунитета (ИКТИ) позволили увеличить общую и бессобытийную …
High sensitivity c-reactive protein and circulating biomarkers of endothelial dysfunction in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors
N Aghel, D Gustafson, D Delgado… - Leukemia & …, 2023 - Taylor & Francis
Tyrosine kinase inhibitors (TKIs) have revolutionized the management of patients with
chronic myelogenous leukemia (CML); however, they may cause cardiovascular (CV) …
chronic myelogenous leukemia (CML); however, they may cause cardiovascular (CV) …
Construction of Lentiviral Vector for miR-217 Overexpression and Knockdown and Its Effect on CML
X Yang, H Jiang, C Sun - Molecular Biotechnology, 2023 - Springer
We attempted to construct a myeloid leukemia cell strain for stable overexpression and
knock-down of miR-217 and explored the possible mechanism underlying miR-217 in …
knock-down of miR-217 and explored the possible mechanism underlying miR-217 in …
[HTML][HTML] miR-497-5p induces apoptosis in K562 cells by downregulating ROCK1
N Chen, Z Meng, J Song, L Kong, Y Zhang… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Objective: To validate the role of miR-497-5p in apoptosis in K562 cells by targeting Rho-
associated kinase isoform 1 (ROCK1). Methods: From January, 2017 to February, 2019, 57 …
associated kinase isoform 1 (ROCK1). Methods: From January, 2017 to February, 2019, 57 …