As obesity and diabetes reach epidemic proportions in the developed world, the role of
insulin resistance and its consequences are gaining prominence. Understanding the role of …

Nitric oxide (NO) is undoubtedly quite an important intercellular messenger in cerebral and
peripheral hemodynamics. This molecule, formed by constitutive isomers of NO synthase …

The existence of a subgroup of normal-weight individuals displaying obesity-related
phenotypic characteristics was first proposed in 1981. These individuals were identified as …

Well-known risk factors for atherosclerosis include hypercholesterolaemia, hypertension,
diabetes, and smoking. These conditions are associated with endothelial dysfunction, which …

Obesity is a worldwide epidemic with multiple obesity-associated health problems including
type 2 diabetes, hypertension, and cardiovascular disease. Adipose tissue serves as a fuel …

In recent years, an explosion of research related to the cellular and vascular
accompaniments of the metabolic syndrome has generated intense interest and controversy …

Large‐scale clinical trials have demonstrated that metabolic control achieved early in the
course of diabetes substantially reduces development and progression of diabetes and the …

Various antenatal events impair nephrogenesis in humans as well as in several animal
models. The consecutive low nephron endowment may contribute to an increased risk for …

An imbalance between reactive oxygen species and antioxidant reserve, referred to as
oxidative stress, results in the altered structure and function of proteins, lipids and DNA …

Low birth weight is associated with an increased risk of hypertension and renal dysfunction
at adulthood. Such an association has been shown to involve a reduction of nephron …