Multimorbidity

ST Skou, FS Mair, M Fortin, B Guthrie… - Nature Reviews …, 2022 - nature.com
Multimorbidity (two or more coexisting conditions in an individual) is a growing global
challenge with substantial effects on individuals, carers and society. Multimorbidity occurs a …

Deprescribing in the older patient: a narrative review of challenges and solutions

H Wu, L Kouladjian O'Donnell, K Fujita… - … journal of general …, 2021 - Taylor & Francis
Polypharmacy is a major challenge in healthcare for older people, and is associated with
increased risks of adverse outcomes, such as delirium, falls, frailty, cognitive impairment and …

[HTML][HTML] Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis.

J Reeve, M Maden, R Hill, A Turk… - Health Technology …, 2022 - ncbi.nlm.nih.gov
BACKGROUND Tackling problematic polypharmacy requires tailoring the use of medicines
to individual needs and circumstances. This may involve stopping medicines (deprescribing) …

Barriers and enablers of healthcare providers to deprescribe cardiometabolic medication in older patients: a focus group study

J Abou, S Crutzen, V Tromp, M Heringa, R Van Marum… - Drugs & aging, 2022 - Springer
Introduction Benefits and risks of preventive medication change over time for ageing patients
and deprescribing of medication may be needed. Deprescribing of cardiovascular and …

[HTML][HTML] Artificial intelligence-supported web application design and development for reducing polypharmacy side effects and supporting rational drug use in geriatric …

SH Akyon, FC Akyon, TE Yılmaz - Frontiers in Medicine, 2023 - frontiersin.org
Introduction: The main complications of polypharmacy, which is known as the simultaneous
use of more than five drugs, are potentially inappropriate medicines (PIMs), drug-drug, and …

How willing are patients or their caregivers to deprescribe: a systematic review and meta-analysis

YL Chock, YL Wee, SL Gan, KW Teoh, KY Ng… - Journal of General …, 2021 - Springer
Background Polypharmacy is associated with the increased use of potentially inappropriate
medications, where the risks of medicine use outweigh its benefits. Stopping medicines …

Polypharmacy and deprescribing in older adults

W Thompson, EG McDonald - Annual Review of Medicine, 2024 - annualreviews.org
Older adults commonly end up on many medications. Deprescribing is an important part of
individualizing care for older adults. It is an opportunity to discuss treatment options and …

Effectiveness of bundled hyperpolypharmacy deprescribing compared with usual care among older adults: a randomized clinical trial

LJ Herrinton, K Lo, M Alavi, SE Alexeeff… - JAMA Network …, 2023 - jamanetwork.com
Importance Older patients using many prescription drugs (hyperpolypharmacy) may be at
increased risk of adverse drug effects. Objective To test the effectiveness and safety of a …

“Kind of blurry”: Deciphering clues to prevent, investigate and manage prescribing cascades

B Farrell, E Galley, L Jeffs, P Howell, LM McCarthy - PloS one, 2022 - journals.plos.org
Background Prescribing cascades, where a medication is used to treat the side effect of
another medication, contribute to polypharmacy and related morbidity. Little is known about …

Barriers and facilitators of successful deprescribing as described by older patients living with frailty, their informal carers and clinicians: a qualitative interview study

G Peat, B Fylan, I Marques, DK Raynor, L Breen… - BMJ open, 2022 - bmjopen.bmj.com
Objective To explore the barriers/facilitators to deprescribing in primary care in England from
the perspectives of clinicians, patients living with frailty who reside at home, and their …