The development of new methods for delivering proteins into cells is a central challenge for
advancing both basic research and therapeutic applications. We previously reported that …

Protein transduction domains such as those derived from the HIV protein TAT have great
potential as vectors for delivery of therapeutic entities such as genes and proteins into cells …

2019-02-22 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …

The therapeutic efficacy of a drug depends on its ability to reach the desired target tissues,
cells, and even intracellular organelles. However, these biological structures are highly …

HIV-1 Tat protein contributes to HIV-neuropathogenesis in several ways including its ability
to be taken up by uninfected bystander CNS cells and to activate inflammatory host genes …

A platform technology has been developed and tested for delivery of intracellular-acting
peptides through electrostatically complexed nanoparticles, or nano-polyplexes, formulated …

Targeted delivery of cancer therapeutics and imaging agents aims to enhance the
accumulation of these molecules in a solid tumor while avoiding uptake in healthy tissues …

The increased need for macromolecular therapeutics, such as peptides, proteins and
nucleotides, to reach intracellular targets necessitates more effective delivery vectors and a …

The application of cell-penetrating peptides (CPPs) for delivering various cargo molecules
with biological functions into cells has gained much attention in recent years. However, the …

Despite the increasing need for antibiotics to fight infectious diseases, fewer new antibiotics
are available on the market. Unfortunately, developing a new class of antibiotics is …