Chronic hepatitis B virus (HBV) infection remains a major health problem worldwide.
Because current anti-HBV treatments are only virostatic, there is an urgent need for …

Three anionic conjugated polyelectrolytes (CPEs) with poly (p-phenylene ethynylene
thiophene) backbones were designed and synthesized, among which PPET3-CO2Na …

Since their discovery, cell-penetrating peptides (CPPs) have provided a novel, efficient, and
non-invasive mode of transport for various (bioactive) cargos into cells. Despite the ever …

Macropinocytosis refers to the nonselective uptake of extracellular molecules into many
different types of eukaryotic cells within large fluid-filled vesicles named macropinosomes …

A dimeric branched peptide TATp-D designed as an analogue of the HIV-Tat protein
transduction domain (TATp), a prototypical cell penetrating peptide (CPP), demonstrates …

A key challenge in developing protein therapeutics or imaging agents that work against
cytosolic targets is the intracellular delivery barrier. Here, we show that the pH-responsive …

This commentary underscores the following aspects of Cell Permeable
Peptides/Transduction Peptides (CPP/PTD) research. First the discovery of CPP/PTD takes …

Finding a highly effective drug delivery carrier with low cytotoxicity is essential for disease
therapy. In this work, we design a cell-penetrating copolymer (CPC) carrier, in which the …

Successful clinical implementation of gene delivery relies on the use of viral or non‐viral
based vectors to package and protect the therapeutic nucleic acid. These vehicles must also …

Due to their modularity and ability to be reprogrammed to recognize a wide range of DNA
sequences, Cys 2-His 2 zinc-finger DNA-binding domains have emerged as useful tools for …