Curcumin (diferuloylmethane), an orange-yellow component of turmeric or curry powder, is a
polyphenol natural product isolated from the rhizome of the plant Curcuma longa. For …

To investigate whether the tumor suppressor gene PTEN affects the activity of the androgen
receptor (AR), we monitored the expression of the apoptotic gene HA-Bax (inserted in an …

Abstract In the United States, prostate cancer (PCa) is the most commonly diagnosed non-
cutaneous cancer in males and the second leading cause of cancer-related death for men …

The normal prostate and early-stage prostate cancers depend on androgens for growth and
survival, and androgen ablation therapy causes them to regress. Cancers that are not cured …

Abstract The Androgen Receptor (AR), a member of the steroid hormone receptor family,
plays important roles in the physiology and pathology of diverse tissues. AR ligands, which …

The androgen receptor (AR), ligand-induced transcription factor, is expressed in primary
prostate cancer and in metastases. AR regulates multiple cellular events, proliferation …

Castration-recurrent prostate cancer (CRPC) is suspected to depend on androgen receptor
(AR). The AF-1 region in the amino-terminal domain (NTD) of AR contains most, if not all, of …

The androgen receptor (AR) signaling axis plays a critical role in the development, function
and homeostasis of the prostate. The classical action of AR is to regulate gene …

Sex differences in the biology of different organ systems and the influence of sex hormones
in modulating health and disease are increasingly relevant in clinical and research areas …

Previous work in the endocrine and neuroendocrine fields has viewed the androgen
receptor (AR) as a transcription factor activated by testosterone or one of its many …