Background Animal studies and trials in older children and adults suggest that a'one dose
per day'regimen of gentamicin is superior to a'multiple doses per day'regimen. Objectives To …

Gentamicin is an aminoglycoside antibiotic with a small therapeutic window that is currently
used primarily as part of short-term empirical combination therapy. Gentamicin dosing …

Linked Articles This article is commented on in the editorial by Holford NHG and Anderson
BJ. Why standards are useful for predicting doses. Br J Clin Pharmacol 2017; 83: 685–7. doi …

Glomerular filtration rate (GFR) is an important measure of renal function. Various models for
its maturation have recently been compared; however, these have used markers, which are …

Sepsis remains a major cause of mortality and morbidity in neonates, and, as a
consequence, antibiotics are the most frequently prescribed drugs in this vulnerable patient …

Background Preterm neonates are usually not part of a traditional drug development
programme, however they are frequently administered medicines. Developing modelling …

Background Developmental physiology can alter pharmacotherapy in preterm populations.
Because of ethical and clinical constraints in studying this vulnerable age group …

The limit for possible survival after extremely preterm birth has steadily improved and
consequently, more premature neonates with increasingly lower gestational age at birth now …

Due to complex maturational and physiological changes that characterize neonates and
affect their response to pharmacological treatments, neonatal pharmacology is different from …

Trough gentamicin therapeutic drug monitoring (TDM) is time-consuming, disruptive to
neonatal clinical care, and a patient safety issue. Bayesian models could allow TDM to be …