The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …

Gap junction channels facilitate the intercellular exchange of ions and small molecules.
While this process is critical to all multicellular organisms, the proteins that form gap junction …

Abstract Pannexin 1 (PANX1) is an ATP-permeable channel with critical roles in a variety of
physiological functions such as blood pressure regulation, apoptotic cell clearance and …

Pannexins are large-pore forming channels responsible for ATP release under a variety of
physiological and pathological conditions. Although predicted to share similar membrane …

Adenosine triphosphate (ATP) has been well established as an important extracellular
ligand of autocrine signaling, intercellular communication, and neurotransmission with …

Three family members compose the pannexin family of channel-forming glycoproteins
(Panx1, Panx2 and Panx3). Their primary function is defined by their capacity to form single …

Extracellular adenosine triphosphate (ATP) serves as a signal for diverse physiological
functions, including spread of calcium waves between astrocytes, control of vascular oxygen …

Abstract The nucleotide adenosine 5′-triphosphate (ATP) has classically been considered
the cell's primary energy currency. Importantly, a novel role for ATP as an extracellular …

Probenecid is a well-established drug for the treatment of gout and is thought to act on an
organic anion transporter, thereby affecting uric acid excretion in the kidney by blocking …

Pannexins, a class of membrane channels, bear significant sequence homology with the
invertebrate gap junction proteins, innexins, and more distant similarities in their membrane …