Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …

The utility of the urinary proteome in infectious diseases remains unclear. Here, we analyzed
the proteome and metabolome of urine and serum samples from patients with COVID-19 …

Mammalian kidneys constantly filter large amounts of liquid, with almost complete retention
of albumin and other macromolecules in the plasma. Breakdown of the three-layered renal …

The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming
interdigitating foot processes with intervening slit diaphragms, disruption in which results in …

Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …

Lupus nephritis (LN) is a common complication of systemic lupus erythematosus (SLE) and
a major risk factor for morbidity and mortality. The abundant cell-free nucleic (DNA/RNA) in …

Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibitors have pleiotropic properties
beyond blood glucose–lowering effects and modify important nonglycemic pathways …

Sirtuins belong to an evolutionarily conserved family of NAD+-dependent deacetylases that
share multiple cellular functions related to proliferation, DNA repair, mitochondrial energy …

Kidney involvement confers significant morbidity and mortality in patients with systemic
lupus erythematosus (SLE). The pathogenesis of lupus nephritis (LN) involves diverse …