The use of nanotechnology has the potential to revolutionize the detection and treatment of
cancer. Developments in protein engineering and materials science have led to the …

Protein-based therapeutics are an attractive alternative to established therapeutic
approaches and represent one of the fastest growing families of drugs. While many of these …

The blood‐brain barrier (BBB) is a semipermeable and extremely selective system in the
central nervous system of most vertebrates, that separates blood from the brain's …

Since the 2013 Nobel Prize was awarded for the discovery of vesicle trafficking, a subgroup
of nanovesicles called exosomes has been driving the research field to a new regime for …

The blood–brain barrier represents a significant challenge for the treatment of high-grade
gliomas, and our understanding of drug transport across this critical biointerface remains …

Background Parkinson's disease (PD) is a progressive neurodegenerative disorder. Owing
to the presence of blood–brain barrier (BBB), conventional pharmaceutical agents are …

Immunotherapy with toll like receptor 9 (TLR9) agonist CpG ODN offers an emergent
strategy to treat life‐threatening malignant glioma. CpG is typically applied invasively by …

Central nervous system (CNS) diseases are among the most difficult to treat, mainly
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …

The delivery of therapeutic molecules to the brain remains an unsolved problem to the
researchers due to the existence of the blood–brain barrier (BBB), which halts the entry of …

Glioblastoma multiforme (GBM) is an aggressive brain tumor with high mortality rates. Due to
its invasiveness, heterogeneity, and incomplete resection, the treatment is very challenging …