Metabolic messengers: FGF21

KH Flippo, MJ Potthoff - Nature metabolism, 2021 - nature.com
As a non-canonical fibroblast growth factor, fibroblast growth factor 21 (FGF21) functions as
an endocrine hormone that signals to distinct targets throughout the body. Interest in …

[HTML][HTML] The nuanced metabolic functions of endogenous FGF21 depend on the nature of the stimulus, tissue source, and experimental model

RA Spann, CD Morrison, LJ den Hartigh - Frontiers in endocrinology, 2022 - frontiersin.org
Fibroblast growth factor 21 (FGF21) is a hormone that is involved in the regulation of lipid,
glucose, and energy metabolism. Pharmacological FGF21 administration promotes weight …

[PDF][PDF] FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes

M Abu-Odeh, Y Zhang, SM Reilly, N Ebadat, O Keinan… - Cell reports, 2021 - cell.com
The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show
that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires …

Brown adipose tissue-derived metabolites and their role in regulating metabolism

K Ziqubu, PV Dludla, SE Mabhida, BU Jack, S Keipert… - Metabolism, 2023 - Elsevier
The discovery and rejuvenation of metabolically active brown adipose tissue (BAT) in adult
humans have offered a new approach to treating obesity and metabolic diseases. Beyond …

Adipokines in glucose and lipid metabolism

X Wang, S Zhang, Z Li - Adipocyte, 2023 - Taylor & Francis
Adipokines are proteins secreted by adipose tissue to regulate glucolipid metabolism and
play vital roles in our body. Different adipokines have more than one endocrine function and …

Levels of β-klotho determine the thermogenic responsiveness of adipose tissues: involvement of the autocrine action of FGF21

R Moure, M Cairó, S Morón-Ros… - American Journal …, 2021 - journals.physiology.org
Fibroblast growth factor-21 (FGF21) is a hormonal regulator of metabolism; it promotes
glucose oxidation and the thermogenic capacity of adipose tissues. The levels of β-klotho …

Endocrine fibroblast growth factors in relation to stress signaling

M Shimizu, R Sato - Cells, 2022 - mdpi.com
Fibroblast growth factors (FGFs) play important roles in various growth signaling processes,
including proliferation, development, and differentiation. Endocrine FGFs, ie, atypical FGFs …

Beige adipocyte as the flame of white adipose tissue: Regulation of browning and impact of obesity

AE Altınova - The Journal of Clinical Endocrinology & …, 2022 - academic.oup.com
Beige adipocyte, the third and relatively new type of adipocyte, can emerge in white adipose
tissue (WAT) under thermogenic stimulations that is termed as browning of WAT. Recent …

[HTML][HTML] FGF21 增强线粒体功能抑制猪卵巢颗粒细胞凋亡

胡亚美, 宋湘容, 黄亮, 张璐通, 高磊, 庞卫军, 杨公社… - 畜牧兽医学报, 2023 - xml-data.org
旨在探究成纤维细胞生长因子21 (fibroblast growth factor 21, FGF21) 对猪(Sus scrofa)
卵巢颗粒细胞凋亡的作用及其调控机制. 本研究采集大白× 长白二元杂交母猪((8±1) 月龄) …

Leptin, acting at central level, increases FGF21 expression in white adipose tissue via PPARβ/δ

L Mazuecos, C Pintado, B Rubio… - International Journal of …, 2021 - mdpi.com
The altered function of adipose tissue can result in obesity, insulin resistance, and its
metabolic complications. Leptin, acting on the central nervous system, modifies the …