Zebrafish: an emerging real-time model system to study Alzheimer's disease and neurospecific drug discovery

S Saleem, RR Kannan - Cell death discovery, 2018 - nature.com
Zebrafish (Danio rerio) is emerging as an increasingly successful model for translational
research on human neurological disorders. In this review, we appraise the high degree of …

Zebrafish models in neuropsychopharmacology and CNS drug discovery

KM Khan, AD Collier, DA Meshalkina… - British journal of …, 2017 - Wiley Online Library
Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular
mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized …

Zebrafish models of autism spectrum disorder

DA Meshalkina, MN Kizlyk, EV Kysil, AD Collier… - Experimental …, 2018 - Elsevier
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized
by motor, social and cognitive deficits that develop early during childhood. The …

Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments relevant to autism

OH Kim, HJ Cho, E Han, TI Hong, K Ariyasiri, JH Choi… - Molecular Autism, 2017 - Springer
Background DYRK1A maps to the Down syndrome critical region at 21q22. Mutations in this
kinase-encoding gene have been reported to cause microcephaly associated with either …

The zebrafish as a promising tool for modeling human brain disorders: A review based upon an IBNS Symposium

S Shams, J Rihel, JG Ortiz, R Gerlai - Neuroscience & Biobehavioral …, 2018 - Elsevier
The zebrafish represents an excellent compromise between system complexity and practical
simplicity, features that make it useful for modeling and mechanistic analysis of complex …

Technical and conceptual considerations for using animated stimuli in studies of animal behavior

L Chouinard-Thuly, S Gierszewski… - Current …, 2017 - academic.oup.com
Rapid technical advances in the field of computer animation (CA) and virtual reality (VR)
have opened new avenues in animal behavior research. Animated stimuli are powerful tools …

Social behavior of zebrafish: from synthetic images to biological mechanisms of shoaling

R Gerlai - Journal of Neuroscience Methods, 2014 - Elsevier
The zebrafish strikes a good balance between system complexity and practical simplicity
and as a result it is becoming increasingly frequently utilized in biomedical research as a …

The zebrafish for preclinical psilocybin research

O Syed, B Tsang, R Gerlai - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
In this review, we discuss the possible utility of zebrafish in research on psilocybin, a
psychedelic drug whose recreational use as well as possible clinical application are gaining …

Overview of beneficial effects of (poly) phenol metabolites in the context of neurodegenerative diseases on model organisms

D Carregosa, S Mota, S Ferreira, B Alves-Dias… - Nutrients, 2021 - mdpi.com
The rise of neurodegenerative diseases in an aging population is an increasing problem of
health, social and economic consequences. Epidemiological and intervention studies have …

Neurochemical and behavioral responses to unpredictable chronic mild stress following developmental isolation: the zebrafish as a model for major depression

N Fulcher, S Tran, S Shams, D Chatterjee, R Gerlai - Zebrafish, 2017 - liebertpub.com
Unpredictable chronic mild stress (UCMS) and developmental social isolation are often
utilized in laboratory animals to mimic unpredictable life stressors and early life adversity …