The outstanding clinical success of immune checkpoint blockade has revived the interest in
underlying mechanisms of the immune system that are capable of eliminating tumors even …

Background Somatic mutations have the potential to encode “non-self” immunogenic
antigens. We hypothesized that tumors with a large number of somatic mutations due to …

Identification of human leukocyte antigen (HLA)-bound peptides by liquid chromatography-
tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules …

Immune checkpoint inhibitors, which unleash a patient's own T cells to kill tumors, are
revolutionizing cancer treatment. To unravel the genomic determinants of response to this …

Background. A new endemic disease has spread across Wuhan City, China, in December
2019. Within few weeks, the World Health Organization (WHO) announced a novel …

We conducted a pilot clinical trial testing a personalized vaccine generated by autologous
dendritic cells (DCs) pulsed with oxidized autologous whole-tumor cell lysate (OCDC) …

T cell immunity directed against tumor-encoded amino acid substitutions occurs in some
melanoma patients. This implicates missense mutations as a source of patient-specific …

The immune system influences the fate of developing cancers by not only functioning as a
tumour promoter that facilitates cellular transformation, promotes tumour growth and sculpts …

Immunotherapies play critical roles in cancer treatment. However, given that only a few
patients respond to immune checkpoint blockades and other immunotherapeutic strategies …

The task of epitope discovery and vaccine design is increasingly reliant on bioinformatics
analytic tools and access to depositories of curated data relevant to immune reactions and …