Human tumours typically harbour a remarkable number of somatic mutations. If presented
on major histocompatibility complex class I molecules (MHCI), peptides containing these …

Predicting the binding affinity of major histocompatibility complex I (MHC I) proteins and their
peptide ligands is important for vaccine design. We introduce an open-source package for …

It is now well established that the immune system can recognize developing cancers and
that therapeutic manipulation of immunity can induce tumor regression. The capacity to …

The proteasome generates the epitopes presented on human leukocyte antigen (HLA) class
I molecules that elicit CD8+ T cell responses. Reports of proteasome-generated spliced …

Protein arginine methyltransferase (PRMT) 5 is over-expressed in a variety of cancers and
the master transcription regulator E2F1 is an important methylation target. We have explored …

Background Binding of peptides to MHC class I molecules (MHC-I) is essential for antigen
presentation to cytotoxic T-cells. Results Here, we demonstrate how a simple alignment step …

Accumulating evidence suggests that clinically efficacious cancer immunotherapies are
driven by T cell reactivity against DNA mutation–derived neoantigens. However, among the …

The heart is an autoimmune-prone organ. It is crucial for the heart to keep injury-induced
autoimmunity in check to avoid autoimmune-mediated inflammatory disease. However, little …

Limited clinical activity has been seen in osteosarcoma (OS) patients treated with immune
checkpoint inhibitors (ICI). To gain insights into the immunogenic potential of these tumors …

HLA class I molecules reflect the health state of cells to cytotoxic T cells by presenting a
repertoire of endogenously derived peptides. However, the extent to which the proteome …