Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance
Esophageal adenocarcinoma (EAC) has a poor outcome, and targeted therapy trials have
thus far been disappointing owing to a lack of robust stratification methods. Whole-genome …
thus far been disappointing owing to a lack of robust stratification methods. Whole-genome …
Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma
N van Rooij, MM van Buuren, D Philips… - Journal of Clinical …, 2013 - ascopubs.org
Tumor Exome Analysis Reveals Neoantigen-Specific T-Cell Reactivity in an Ipilimumab-Responsive
Melanoma | Journal of Clinical Oncology Skip to main content ASCO Publications Publications …
Melanoma | Journal of Clinical Oncology Skip to main content ASCO Publications Publications …
pVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigens
Cancer immunotherapy has gained significant momentum from recent clinical successes of
checkpoint blockade inhibition. Massively parallel sequence analysis suggests a connection …
checkpoint blockade inhibition. Massively parallel sequence analysis suggests a connection …
T cell epitope predictions
Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of
essentially all cell types. MHC ligands that trigger a T cell immune response are referred to …
essentially all cell types. MHC ligands that trigger a T cell immune response are referred to …
Human CD8+ T cell cross-reactivity across influenza A, B and C viruses
Abstract Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally and
infect humans, with IAV and IBV causing the most severe disease. CD8+ T cells confer cross …
infect humans, with IAV and IBV causing the most severe disease. CD8+ T cells confer cross …
Identification of vaccine targets in pathogens and design of a vaccine using computational approaches
Antigen identification is an important step in the vaccine development process.
Computational approaches including deep learning systems can play an important role in …
Computational approaches including deep learning systems can play an important role in …
Exploiting the mutanome for tumor vaccination
Multiple genetic events and subsequent clonal evolution drive carcinogenesis, making
disease elimination with single-targeted drugs difficult. The multiplicity of gene mutations …
disease elimination with single-targeted drugs difficult. The multiplicity of gene mutations …
MicroRNA control of protein expression noise
JM Schmiedel, SL Klemm, Y Zheng, A Sahay… - Science, 2015 - science.org
MicroRNAs (miRNAs) repress the expression of many genes in metazoans by accelerating
messenger RNA degradation and inhibiting translation, thereby reducing the level of protein …
messenger RNA degradation and inhibiting translation, thereby reducing the level of protein …
Combinatorial therapy in tumor microenvironment: where do we stand?
The tumor microenvironment plays a pivotal role in tumor initiation and progression by
creating a dynamic interaction with cancer cells. The tumor microenvironment consists of …
creating a dynamic interaction with cancer cells. The tumor microenvironment consists of …
Subtractive proteomics to identify novel drug targets and reverse vaccinology for the development of chimeric vaccine against Acinetobacter baumannii
The emergence of drug-resistant Acinetobacter baumannii is the global health problem
associated with high mortality and morbidity. Therefore it is high time to find a suitable …
associated with high mortality and morbidity. Therefore it is high time to find a suitable …