KRAS is one of the most frequently mutated proto-oncogenes in human cancers. The
dominant oncogenic mutations of KRAS are single amino acid substitutions at codon 12, in …

Immunotherapies have emerged as one of the most promising approaches to treat patients
with cancer. Recently, there have been many clinical successes using checkpoint receptor …

Sudden emergence and a rapid outbreak of SARS-CoV-2 accompanied by a devastating
impact on the economy and public health has driven extensive scientific mobilization to …

Immunoinformatics involves the application of computational methods to immunological
problems. Prediction of B-and T-cell epitopes has long been the focus of immunoinformatics …

A number of machine learning-based predictors have been developed for identifying
immunogenic T-cell epitopes based on major histocompatibility complex (MHC) class I and II …

Genomic intratumor heterogeneity (ITH) may be associated with postsurgical relapse of
localized lung adenocarcinomas. Recently, mutations, through generation of neoantigens …

Neoantigen vaccines are based on epitopes of antigenic parts of mutant proteins expressed
in cancer cells. These highly immunogenic antigens may trigger the immune system to …

Binding of peptides to MHC class I (MHC-I) molecules is the most selective event in the
processing and presentation of Ags to CTL, and insights into the mechanisms that govern …

Prediction of HLA binding affinity is widely used to identify candidate T cell epitopes, and an
affinity of 500 nM is routinely used as a threshold for peptide selection. However, the fraction …

Neoantigens are ideal targets for dendritic cell (DC) vaccines. So far, only a few neoantigen-
based DC vaccines have been investigated in clinical trials. Here, we reported a case of a …