Immunotherapy directed against private tumor neo-antigens derived from non-synonymous
somatic mutations is a promising strategy of personalized cancer immunotherapy. However …

Immunotherapy has led to a paradigm shift in the treatment of some malignancies, providing
long-term, durable responses for patients with advanced cancers. However, such therapy …

Immunoinformatics is a new critical field with several tools and databases that conduct the
eyesight of experimental selection and facilitate analysis of the great amount of immunologic …

Immune checkpoint inhibitor induces tumor rejection by activated host immune system. The
anti-tumor immune response consists of capture, presentation, recognition of neoantigen, as …

Proteins created from recurrent fusion genes like CBFB-MYH11 are prevalent in acute
myeloid leukemia (AML), often necessary for leukemogenesis, persistent throughout the …

Highlights•Immunopeptidomics analysis reveals the in vivo antigenic repertoire of
tumors.•Shared cancer antigens and private neo-epitopes are detected by …

Background Experts in peptide: MHC binding studies are often able to estimate the impact of
a single residue substitution based on a heuristic understanding of amino acid similarity in …

Immunotherapy treatment of patients with metastatic cancer has assumed a prominent role
in the clinic. Durable complete response rates of 20% to 25% are achieved in patients with …

Zika virus (ZIKV) is an emerging arbovirus of the Flaviviridae family. Although ZIKV infection
is typically mild and self-limiting in healthy adults, infection has been associated with …

The identification of peptides presented by human leukocyte antigen (HLA) class I is
tremendously important for the understanding of antigen presentation mechanisms under …