Iron is a key nutrient for normal central nervous system (CNS) development and function;
thus, iron deficiency as well as iron excess may result in harmful effects in the CNS …

Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

Objective Iron may contribute to the pathogenesis and progression of multiple sclerosis (MS)
due to its accumulation in the human brain with age. Our study focused on nonheme iron …

Three types of vascular dysfunction have been described in multiple sclerosis (MS). First,
findings from epidemiological studies suggest that patients with MS have a higher risk for …

Objective: Multiple sclerosis (MS) is characterized by demyelination centered around
cerebral veins. Recent studies suggested this topographic pattern may be caused by venous …

A hybrid blood–brain barrier (BBB)-on-chip cell culture device is proposed in this study by
integrating microcontact printing and perfusion co-culture to facilitate the study of BBB …

The exact pathogenesis of multiple sclerosis (MS) is incompletely understood. Although auto-
immune responses have an important role in the development of hallmark focal …

The effect of redox metals such as iron and copper on multiple sclerosis and amyotrophic
lateral sclerosis has been intensively studied. However, the origin of these disorders …

The prevailing view on multiple sclerosis etiopathogenesis has been challenged by the
suggested new entity chronic cerebrospinal venous insufficiency. To test this hypothesis, we …

J. Neurochem.(2012) 120, 7–25. Abstract Iron, an essential element used for a multitude of
biochemical reactions, abnormally accumulates in the CNS of patients with multiple …