The placenta is a vital fetal exchange organ connecting mother and baby. Specialised
placental epithelial cells, called trophoblasts, are essential for adequate placental function …

The aim of this study was to characterize the immediate effects of heat stress on plasma FSH
and inhibin concentrations, and its involvement in follicular dynamics during a complete …

Clusters of enhancers, referred as to super-enhancers (SEs), control the expression of cell
identity genes. The organisation of these clusters, and how they are remodelled upon …

The correct establishment and maintenance of DNA methylation patterns are critical for
mammalian development and the control of normal cell growth and differentiation. DNA …

Ten-eleven translocation (TET) family enzymes convert 5-methylcytosine to 5-
hydroxylmethylcytosine. However, the molecular mechanism that regulates this biological …

DNA methylation controls DNA accessibility to transcription factors and other regulatory
proteins, thereby affecting gene expression and hence cellular identity and function. As …

Gene loci that are hypermethylated and repressed in embryonic (ESCs) but hypomethylated
and expressed in trophoblast (TSCs) stem cells are very rare and may have particularly …

The ten-eleven translocation factor TET1 and its conferred epigenetic modification 5-
hydroxymethylcytosine (5hmC) have important roles in maintaining the pluripotent state of …

Histone citrullination is a relatively poorly studied epigenetic modification that involves the
irreversible conversion of arginine residues into citrulline. It is conferred by a small family of …

Epigenetic changes alter the expression of genes at both pre-and post-transcriptional levels
without changing their DNA sequence. Accumulating evidence suggests that such changes …