Endothelial dysfunction is a systemic pathological state of the endothelium characterized by
a reduction in the bioavailability of vasodilators, essentially nitric oxide, leading to impaired …

An explosion in global epidemic of type 2 diabetes mellitus poses major rise in cases with
vascular endothelial dysfunction ranging from micro-(retinopathy, nephropathy and …

Male Zucker diabetic fatty fa/fa (ZDF) rats develop obesity and insulin resistance at a young
age, and then with aging, progressively develop hyperglycemia. This hyperglycemia is …

Nox generated ROS, particularly those derived from Nox1, Nox2 and Nox4, have emerged
as important regulators of the actin cytoskeleton and cytoskeleton-supported cell functions …

Diabetes promotes renal sympathetic hyperactivity, autonomic imbalance, and
cardiovascular and renal dysfunction. Bilateral renal denervation (BRD) has emerged as a …

Abstract Treatment with cisplatin is associated with dose‐limiting side effects, mainly
nephrotoxicity. On the other hand, nebivolol, a β1‐adrenoceptor antagonist, exhibits …

Abstract Apocynin (4′-hydroxy-3′-methoxyacetophenone) is the most commonly used
NADPH oxidase (Nox) inhibitor. However, its application raises serious controversies, as the …

Abstract Background Cyclosporine A (CsA)-induced nephrotoxicity is a challenging problem
complicating its chronic use in a large array of autoimmune diseases, as well as in organ …

A wide range of microalbuminuria cutoff values are currently used for diagnosing the early
stage of nephropathy in type 2 diabetes (T2D). This study analyzed the relationships …

The aim was to evaluate the effects and mechanisms of nebivolol on renal damage in
Zucker diabetic fatty (ZDF) rats, in comparison with those of atenolol and captopril. Animals …