Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Complex coacervate‐based materials for biomedicine

WC Blocher, SL Perry - Wiley Interdisciplinary Reviews …, 2017 - Wiley Online Library
There has been increasing interest in complex coacervates for deriving and transporting
biomaterials. Complex coacervates are a dense, polyelectrolyte‐rich liquid that results from …

Protein encapsulation using complex coacervates: what nature has to teach us

WC Blocher McTigue, SL Perry - Small, 2020 - Wiley Online Library
Protein encapsulation is a growing area of interest, particularly in the fields of food science
and medicine. The sequestration of protein cargoes is achieved using a variety of methods …

Transfer matrix model of pH effects in polymeric complex coacervation

AR Knoerdel, WC Blocher McTigue… - The Journal of Physical …, 2021 - ACS Publications
Oppositely charged polyelectrolytes can undergo an associative phase separation, in a
process known as polymeric complex coacervation. This phenomenon is driven by the …

Nanostructured Lipid‐Based Films for Substrate‐Mediated Applications in Biotechnology

M Kang, M Tuteja, A Centrone… - Advanced functional …, 2018 - Wiley Online Library
Amphiphilic in nature, lipids spontaneously self‐assemble into a range of nanostructures in
the presence of water. Among lipid self‐assembled structures, liposomes and supported …

The benefit of poor mixing: kinetics of coacervation

WCB McTigue, E Voke, LW Chang… - Physical Chemistry …, 2020 - pubs.rsc.org
Complex coacervation has become a prominent area of research in the fields of food
science, personal care, drug stabilization, and more. However, little has been reported on …

Bioinspired Antimicrobial Coatings from Peptide-Functionalized Liquid Crystalline Nanostructures

M Zabara, Q Ren, H Amenitsch… - ACS Applied Bio …, 2021 - ACS Publications
Surface-associated microbial infections and contaminations are a major challenge in
various fields including the food and health sectors. This study demonstrates the design of …

Soft Nanostructured Films for Actuated Surface‐Based siRNA Delivery

M Kang, C Leal - Advanced Functional Materials, 2016 - Wiley Online Library
Substrate‐mediated gene delivery is an emerging technology that enables spatial control of
gene expression and localized delivery. This is of particular interest for siRNA where surface …

Co‐assembly behavior of oppositely charged thermoresponsive elastin‐like polypeptide block copolymers

JW Choi, TY Heo, H Choi, SH Choi… - Journal of Applied …, 2022 - Wiley Online Library
The formation of complex coacervate core micelles (C3Ms) was observed by mixing two
oppositely charged elastin‐like polypeptides (ELP)‐based diblock copolymers, each …

Mussel adhesion‐inspired reverse transfection platform enhances osteogenic differentiation and bone formation of human adipose‐derived stem cells

J Shin, JH Cho, Y Jin, K Yang, JS Lee, HJ Park… - Small, 2016 - Wiley Online Library
Using small interfering RNA (siRNA) to regulate gene expression is an emerging strategy for
stem cell manipulation to improve stem cell therapy. However, conventional methods of …