Electronic cigarettes and health outcomes: umbrella and systematic review of the global evidence

E Banks, A Yazidjoglou, S Brown… - Medical Journal of …, 2023 - Wiley Online Library
Objective To review and synthesise the global evidence regarding the health effects of
electronic cigarettes (e‐cigarettes, vapes). Study design Umbrella review (based on major …

[HTML][HTML] One is not enough: understanding and modeling polysubstance use

EA Crummy, TJ O'Neal, BM Baskin… - Frontiers in …, 2020 - frontiersin.org
Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted
pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative …

Plants secondary metabolites: the key drivers of the pharmacological actions of medicinal plants

RA Hussein, AA El-Anssary - Herbal medicine, 2019 - books.google.com
The vast and versatile pharmacological effects of medicinal plants are basically dependent
on their phytochemical constituents. Generally, the phytochemical constituents of plants fall …

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

R Karlsson Linnér, P Biroli, E Kong, SFW Meddens… - Nature …, 2019 - nature.com
Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …

Role of plant alkaloids on human health: A review of biological activities

B Debnath, WS Singh, M Das, S Goswami… - Materials today …, 2018 - Elsevier
Alkaloids are plant secondary metabolite. They are well known nitrogen-containing natural
bioactive compounds. Cutting edge research is going on alkaloids to unravel novel …

Association of electronic cigarette use with initiation of combustible tobacco product smoking in early adolescence

AM Leventhal, DR Strong, MG Kirkpatrick, JB Unger… - Jama, 2015 - jamanetwork.com
Importance Exposure to nicotine in electronic cigarettes (e-cigarettes) is becoming
increasingly common among adolescents who report never having smoked combustible …

Neurobiological mechanisms of nicotine reward and aversion

L Wills, JL Ables, KM Braunscheidel, SPB Caligiuri… - Pharmacological …, 2022 - ASPET
Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …

The methylation effect in medicinal chemistry

EJ Barreiro, AE Kümmerle, CAM Fraga - Chemical reviews, 2011 - ACS Publications
The monovalent methyl group is derived from methane through the removal of a hydrogen
atom, 1 and its etymology is directly related to the discovery of methanol. 2 The first reports …

Neuronal and extraneuronal nicotinic acetylcholine receptors

M Zoli, S Pucci, A Vilella, C Gotti - Current neuropharmacology, 2018 - ingentaconnect.com
Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop
ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other …

Lung carcinogenesis by tobacco smoke

SS Hecht - International journal of cancer, 2012 - Wiley Online Library
Cigarette smoke is a complex mixture of chemicals including multiple genotoxic lung
carcinogens. The classic mechanisms of carcinogen metabolic activation to DNA adducts …