The management of retinoblastoma, the most common intraocular malignancy in children,
has changed drastically over the last decade. Landmark developments in local drug …

The overall efficacy of chimeric antigen receptor modified T cells (CARTs) remain limited in
solid tumors despite intensive studies that aim at targeting multiple antigens, enhancing …

How single-chain variable fragments (scFvs) affect the functions of chimeric antigen
receptors (CARs) has not been well studied. Here, the components of CAR with an …

Carbohydrates are abundantly expressed on the surface of both eukaryotic and prokaryotic
cells, often as post translational modifications of proteins. Glycoproteins are recognized by …

Cancer immunotherapy has emerged as a novel anti-tumor treatment. Despite significant
breakthroughs, cancer immunotherapy remains focused on several types of tumors that are …

Part of the broader glycosphingolipid family, gangliosides are composed of a ceramide
bound to a sialic acid-containing glycan chain, and locate at the plasma membrane …

Adoptive T-cell therapy (ACT) is a promising therapeutic approach based on the concept of
potent T-cell mediated immunity against the tumor. The outcome of antigen-specific T-cells …

The limited efficacy of traditional cancer treatments, including chemotherapy, radiotherapy,
and surgery, emphasize the significance of employing innovative methods. CAR (Chimeric …

Over the past few years, the field of pediatric cancer has experienced a shift in momentum,
and this has led to new and exciting findings that have relevance beyond pediatric …

Adoptive T cell therapy using second-generation anti-CD19 chimeric antigen receptor T
cells (anti-CD19-CAR2-T) induced complete remission in many heavily pretreated patients …